Search Result

Results for "

Flt3+ligand

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (2) CCR (1) Cytochrome P450 (1) ERK (2) FAK (1) FLT3 (7) HSP (1) Interleukin Related (1) Ligands for Target Protein for PROTAC (1) MEK (1) p38 MAPK (1) PI3K (1) PROTACs (2) STAT (3) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114323

*PROTAC FLT-3* degrader 1**	PROTACs FLT3 Apoptosis STAT MEK ERK	Cancer
PROTAC FLT-3 degrader 1 is an effective and selective FLT-3 PROTAC degrader with an IC₅₀ of 0.6 nM. PROTAC FLT-3 degrader 1 inhibits both FLT-3 and FLT-3 ITD mutants. PROTAC FLT-3 degrader 1 has the activity of anti-proliferation and induction of apoptosis, which can be used in the study of tumor. (Pink: FLT3 ligand (HY-168702); Black: Linker (HY-124380); Blue: VHL ligand (HY-125845)) .

HY-148070

FLT3-IN-17	FLT3 FAK Cytochrome P450	Cancer
FLT3-IN-17 inhibits CYPs and *FLT3* mutants activity (IC₅₀s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC₅₀ value of 12 nM. FLT3 ligand-2 can be used in the research of cancers .

HY-P991208

Flt-3L-Ig (hum/hum) human Flt3L; hFlt3L	FLT3 Interleukin Related CCR	Inflammation/Immunology
Flt-3L-Ig (hum/hum) (hFlt3L) is a *Flt3* ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of IL-2, CCL2 and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation .

HY-170769

FLT3 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates FLT3	Cancer
FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the *FLT3* ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062). PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases .

HY-168702

FLT3 ligand-2	Ligands for Target Protein for PROTAC	Cancer
FLT3 ligand-2 is a Ligand for Target Protein for PROTAC. FLT3 ligand-2 can be used to synthesize PROTAC FLT-3 degrader 1 (HY-114323) .

HY-110026

GTP-14564	FLT3	Cancer
GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and *FLT3. GTP-14564 inhibits FLT3 ligand*-dependent growth in Ba/F3 leukemia cells .

HY-175273

MA191	PROTACs FLT3 HSP ERK STAT Akt Apoptosis	Cancer
MA191 is a *FLT3* PROTAC degrader. MA191 abrogates *FLT3* inhibitor resistance from rebound activation of mitogen-activated kinases. MA191 mediates rapid *FLT3*-ITD degradation through a mechanism requiring VHL, neddylation, and BIM. MA191 reduces *FLT3*-ITD levels before inducing apoptosis. MA191 halts AML cell proliferation in Danio rerio. MA191 can be used for the study of acute myeloid leukemia (AML) (Pink: FLT3 ligand: (HY-175311), Blue: E3 ligase CRBN Ligand (HY-112078), Black: Linker, E3 ligase ligand-linker conjugate (HY-175312)) .

HY-P991641

IMC-EB10 LY3012218	FLT3 p38 MAPK STAT PI3K Akt	Cancer
IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to *FLT3* with high affinity (K_d = 158 pM) and blocks the binding of *FLT3* ligand to *FLT3* (IC₅₀ ≈ 10 nM), thereby inhibiting MAPK, STAT5, and *PI3K/Akt* signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated *FLT3* receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research ^[3] .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991208

Flt-3L-Ig (hum/hum) human Flt3L; hFlt3L	FLT3 Interleukin Related CCR	Inflammation/Immunology
Flt-3L-Ig (hum/hum) (hFlt3L) is a *Flt3* ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of IL-2, CCL2 and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation .

HY-P991641

IMC-EB10 LY3012218	FLT3 p38 MAPK STAT PI3K Akt	Cancer
IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to *FLT3* with high affinity (K_d = 158 pM) and blocks the binding of *FLT3* ligand to *FLT3* (IC₅₀ ≈ 10 nM), thereby inhibiting MAPK, STAT5, and *PI3K/Akt* signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated *FLT3* receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research ^[3] .

Species:	Human (8) Rhesus Macaque (1) Mouse (3) Rat (1) Cynomolgus (1) Pig (1)
Tag:	His (8) Tag Free (4) MBP (1) Fc (2)
Source:	HEK293 (6) CHO (1) Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704617

	FLT3LG Protein, Human (HEK293) Flt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	HEK293
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (HEK293) is the recombinant human-derived FLT3LG protein, expressed by HEK293, with tag free.

HY-P700072

	FLT3LG Protein, Human Flt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	E. coli
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human is the recombinant human-derived FLT3LG protein, expressed by E. coli , with tag free.

HY-P700072AF

	Animal-Free FLT3LG Protein, Human (His) Flt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	E. coli
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. Animal-Free FLT3LG Protein, Human (His) is the recombinant human-derived animal-FreeFLT3LG protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P72802

	FLT3LG Protein, Macaca nemestrina/Cynomolgus Fms related receptor tyrosine kinase 3 ligand; Flt3LG; Flt-3 Ligand	Rhesus Macaque;Cynomolgus	E. coli
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Macaca nemestrina/Cynomolgus is the recombinant Rhesus Macaque-derived FLT3LG protein, expressed by E. coli , with tag free.

HY-P700238AF

	Animal-Free FLT3LG Protein, Pig (His) Fms-Felated Tyrosine Kinase 3 Ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Pig	E. coli
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. Animal-Free FLT3LG Protein, Pig (His) is the recombinant pig-derived animal-FreeFlt-3 Ligand protein, expressed by E. coli, with C-His labeled tag. This product is for cell culture use only.

HY-P74150

	FLT3LG Protein, Rat (sf9, His) Fms-related tyrosine kinase 3 ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Rat	Sf9 insect cells
	The FLT3LG protein has the same protein-binding and receptor tyrosine kinase-binding activities predicted to positively regulate natural killer cell proliferation. Intended to be located on the cell surface and extracellular space, it serves as an intrinsic component on the outside of the plasma membrane. FLT3LG Protein, Rat (sf9, His) is the recombinant rat-derived FLT3LG protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P73066

	FLT3LG Protein, Human (sf9, His) Fms-related tyrosine kinase 3 ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Human	Sf9 insect cells
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (sf9, His) is the recombinant human-derived FLT3LG protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73067

	FLT3LG Protein, Mouse (HEK293, Fc) Fms-related tyrosine kinase 3 ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Mouse	HEK293
	FLT3LG protein, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70563

	FLT3LG Protein, Mouse (HEK293, His) 1 Publications Verification Fms-related tyrosine kinase 3 ligand (Flt3L); SL cytokine; Flt3 ligand	Mouse	HEK293
	FLT3LG protein, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704173

	FLT3LG Protein, Human (HEK293, Fc) Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine; Flt3LG	Human	HEK293
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (HEK293, Fc) is the recombinant human-derived FLT3 Ligand protein, expressed by HEK293, with C-hFc labeled tag.

HY-P70544

	FLT3LG Protein, Human (HEK293, His) Fms-Felated Tyrosine Kinase 3 Ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Human	HEK293
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7111

	FLT3LG Protein, Human (CHO) 1 Publications Verification rHuFlt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	CHO
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (CHO) is the recombinant human-derived FLT3LG protein, expressed by CHO cells , with tag free.

HY-P70544G

	GMP FLT3LG Protein, Human (HEK293, His) Fms-related tyrosine kinase 3 ligand; Flt3L; SL cytokine; Flt3LG	Human	HEK293
	FLT3LG protein, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. GMP FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700177AF

	Animal-Free FLT3LG Protein, Mouse (His) rMuFlt-3 Ligand, His; Fms-related tyrosine kinase 3 ligand; SL cytokine; Flt3lg	Mouse	E. coli
	FLT3LG protein, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. Animal-Free FLT3LG Protein, Mouse (His) is the recombinant mouse-derived animal-FreeFLT3LG protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.