2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. FLT3 ligand-2

FLT3 ligand-2 is a Ligand for Target Protein for PROTAC. FLT3 ligand-2 can be used to synthesize PROTAC FLT-3 degrader 1 (HY-114323).

For research use only. We do not sell to patients.

FLT3 ligand-2

FLT3 ligand-2 Chemical Structure

CAS No. : 950769-51-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

FLT3 ligand-2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

FLT3 ligand-2 is a Ligand for Target Protein for PROTAC. FLT3 ligand-2 can be used to synthesize PROTAC FLT-3 degrader 1 (HY-114323)[1].

Cellular Effect
Cell Line Type Value Description References
MV4-11 IC50
0.15 nM
Compound: 6b
Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer-blue cell viability assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer-blue cell viability assay
[PMID: 19754199]
Molecular Weight

447.51

Formula

C23H21N5O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=C(N3C(S2)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2346 mL 11.1729 mL 22.3459 mL
5 mM 0.4469 mL 2.2346 mL 4.4692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2346 mL 11.1729 mL 22.3459 mL 55.8647 mL
5 mM 0.4469 mL 2.2346 mL 4.4692 mL 11.1729 mL
10 mM 0.2235 mL 1.1173 mL 2.2346 mL 5.5865 mL
15 mM 0.1490 mL 0.7449 mL 1.4897 mL 3.7243 mL
20 mM 0.1117 mL 0.5586 mL 1.1173 mL 2.7932 mL
25 mM 0.0894 mL 0.4469 mL 0.8938 mL 2.2346 mL
30 mM 0.0745 mL 0.3724 mL 0.7449 mL 1.8622 mL
40 mM 0.0559 mL 0.2793 mL 0.5586 mL 1.3966 mL
50 mM 0.0447 mL 0.2235 mL 0.4469 mL 1.1173 mL
60 mM 0.0372 mL 0.1862 mL 0.3724 mL 0.9311 mL
80 mM 0.0279 mL 0.1397 mL 0.2793 mL 0.6983 mL
100 mM 0.0223 mL 0.1117 mL 0.2235 mL 0.5586 mL
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FLT3 ligand-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3 ligand-2950769-51-4Ligands for Target Protein for PROTACTarget Protein-binding MoietyLigand for Target Protein for PROTACPROTAC FLT-3 degrader 1Inhibitorinhibitorinhibit

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