Search Result

Results for "

JNK+activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (3) Antifolate (1) Apoptosis (19) Autophagy (8) Bacterial (3) Bcl-2 Family (2) Caspase (5) DNA/RNA Synthesis (3) Endogenous Metabolite (1) Environmental Pollutants (1) ERK (1) Fungal (2) Glutathione S-transferase (2) HIV (4) Isotope-Labeled Compounds (2) JNK (15) MHC (1) Microtubule/Tubulin (2) p38 MAPK (4) Parasite (2) Reactive Oxygen Species (ROS) (5) Reference Standards (6) Reverse Transcriptase (4) TNF Receptor (1)
By Research Areas:	Cancer (16) Infection (9) Inflammation/Immunology (1) Neurological Disease (1)

By Targets:

Akt (2)

Antibiotic (3)

Antifolate (1)

Apoptosis (19)

Autophagy (8)

Bacterial (3)

Bcl-2 Family (2)

Caspase (5)

DNA/RNA Synthesis (3)

Endogenous Metabolite (1)

Environmental Pollutants (1)

ERK (1)

Fungal (2)

Glutathione S-transferase (2)

HIV (4)

Isotope-Labeled Compounds (2)

JNK (15)

MHC (1)

Microtubule/Tubulin (2)

p38 MAPK (4)

Parasite (2)

Reactive Oxygen Species (ROS) (5)

Reference Standards (6)

Reverse Transcriptase (4)

TNF Receptor (1)

By Research Areas:

Cancer (16)

Infection (9)

Inflammation/Immunology (1)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18982

Anisomycin 135+ Cited Publications Flagecidin; Wuningmeisu C	DNA/RNA Synthesis JNK Bacterial Apoptosis Antibiotic Parasite	Infection Cancer
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system . Anisomycin is a *JNK* activator, which increases phospho-JNK . Anisomycin is a bacterial antibiotic .

HY-13634A

Ezatiostat 5+ Cited Publications TER199free base; TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .

HY-B1839

Fluazinam	Environmental Pollutants JNK Fungal p38 MAPK Bcl-2 Family Caspase Autophagy Apoptosis	Infection
Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of *JNK*, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees .

HY-14266

Dapivirine 2 Publications Verification TMC120; R147681	HIV Reverse Transcriptase Apoptosis Autophagy	Infection
Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-N6872

Actein	JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting *ROS/JNK* activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-W753791

(±)-Perillaldehyde	TNF Receptor JNK	Neurological Disease Inflammation/Immunology
(±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing *JNK* activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC₅₀ of 171.7 μM .

HY-18982R

Anisomycin (Standard) Flagecidin (Standard); Wuningmeisu C (Standard)	Reference Standards DNA/RNA Synthesis JNK Bacterial Apoptosis Antibiotic Parasite	Infection Cancer
Anisomycin (Standard) is the analytical standard of Anisomycin. This product is intended for research and analytical applications. Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].

HY-B1839R

Fluazinam (Standard)	Reference Standards Fungal JNK p38 MAPK Bcl-2 Family Caspase Autophagy Apoptosis	Infection
Fluazinam (Standard) is the analytical standard of Fluazinam (HY-B1839). This product is intended for research and analytical applications. Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of *JNK*, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees .

HY-B0510CR

Trimethoprim lactate (Standard)	Reference Standards Antifolate Bacterial Antibiotic	Infection Cancer
Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-120349

LL-Z1640-4	p38 MAPK JNK Apoptosis Reactive Oxygen Species (ROS)	Cancer
LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and *JNK* activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4 .

HY-101287

MPT0B392	Microtubule/Tubulin JNK Apoptosis Caspase	Cancer
MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .

HY-N3828

epi-Eriocalyxin A	Apoptosis ERK JNK	Cancer
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits ERK1/2 and *JNK* activation, which suppresses Bcl-2 expression .

HY-13634

Ezatiostat hydrochloride TER199; TLK199 hydrochloride	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment .

HY-14266R

Dapivirine (Standard) TMC120 (Standard); R147681 (Standard)	HIV Reverse Transcriptase Apoptosis Autophagy Reference Standards	Infection
Dapivirine (Standard) is the analytical standard of Dapivirine. This product is intended for research and analytical applications. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-179044

*MKK7-JNK activator* 1**	p38 MAPK JNK Caspase Apoptosis	Cancer
MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production). MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC) .

HY-162886

BSO-07	JNK Reactive Oxygen Species (ROS)	Cancer
BSO-07 is a *ROS/JNK* activator with significant anticancer effects, having an IC₅₀ value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .

HY-122315

Oncrasin-60 NSC-741909	JNK Apoptosis	Cancer
Oncrasin-60 (NSC-741909) is a compound with antitumor activity that is active against multiple cancer cell lines in vitro and can induce tumor regression in vivo, with its mechanism involving JNK activation and STAT3 inhibition.

HY-14266S

Dapivirine-d11 TMC120-d₁₁; R147681-d₁₁	Isotope-Labeled Compounds HIV Reverse Transcriptase Apoptosis Autophagy	Infection
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-N6872R

Actein (Standard)	Reference Standards JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-14266S1

Dapivirine-d4 TMC120-d₄; R147681-d₄	Isotope-Labeled Compounds Apoptosis Reverse Transcriptase Autophagy HIV	Infection
Dapivirine-d₄ (TMC120-d₄) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-130207

Oncrasin-72 NSC-743380	Endogenous Metabolite DNA/RNA Synthesis	Cancer
Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma .

HY-P991590

1D09C3	MHC Apoptosis JNK Reactive Oxygen Species (ROS)	Cancer
1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, *JNK* activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL) .

HY-101287R

MPT0B392 (Standard)	Microtubule/Tubulin Reference Standards JNK Apoptosis Caspase	Cancer
MPT0B392 (Standard) is the analytical standard of MPT0B392 (HY-101287). This product is intended for research and analytical applications. MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .

Cat. No.	Product Name	Target	Research Area