2. MAPK/ERK Pathway PI3K/Akt/mTOR Apoptosis Autophagy
  3. JNK Akt Apoptosis Autophagy
  4. Actein

Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo.

For research use only. We do not sell to patients.

Actein Chemical Structure

Actein Chemical Structure

CAS No. : 18642-44-9

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5 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

Actein Related Antibodies

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JNK1 JNK2 JNK3 JNK

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Description

Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo[1][2].

Molecular Weight

676.83

Formula

C37H56O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]3([H])[C@@]4(C[C@@H](OC(C)=O)[C@@]1([C@]5([H])[C@](O[C@]6([C@H]7[C@]([C@@H](O)O6)(C)O7)C[C@H]5C)([H])C2)C)[C@@]8([C@@](C(C)([C@@H](O[C@@]9([H])[C@@H]([C@H]([C@H](O)CO9)O)O)CC8)C)([H])CC3)C4
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (147.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4775 mL 7.3874 mL 14.7748 mL
5 mM 0.2955 mL 1.4775 mL 2.9550 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4775 mL 7.3874 mL 14.7748 mL 36.9369 mL
5 mM 0.2955 mL 1.4775 mL 2.9550 mL 7.3874 mL
10 mM 0.1477 mL 0.7387 mL 1.4775 mL 3.6937 mL
15 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4625 mL
20 mM 0.0739 mL 0.3694 mL 0.7387 mL 1.8468 mL
25 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
30 mM 0.0492 mL 0.2462 mL 0.4925 mL 1.2312 mL
40 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9234 mL
50 mM 0.0295 mL 0.1477 mL 0.2955 mL 0.7387 mL
60 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6156 mL
80 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4617 mL
100 mM 0.0148 mL 0.0739 mL 0.1477 mL 0.3694 mL
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Actein Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Actein18642-44-9JNKAktApoptosisAutophagyc-Jun N-terminal kinasePKBProtein kinase BInhibitorinhibitorinhibit

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