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PDI+inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Bacterial (1) Environmental Pollutants (1) MDM-2/p53 (1) PDI (14) Reference Standards (3)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107193

Bacitracin 3 Publications Verification	Environmental Pollutants Antibiotic Bacterial PDI	Infection Cancer
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

HY-100432

LOC14 4 Publications Verification	PDI	Neurological Disease Inflammation/Immunology
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-100430

CCF642 1 Publications Verification	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-100433

PACMA 31 5 Publications Verification	PDI	Cancer
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111117

3-Methyltoxoflavin 1 Publications Verification	PDI	Cancer
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC₅₀ of 170 nM.

HY-N2163

Mudanpioside C	PDI	Cardiovascular Disease
Mudanpioside C is a protein disulfide isomerase (PDI) inhibitor with a human IC₅₀ of 3.31 μM and human K_d of 3.9 μM. Mudanpioside C suppresses collagen-induced platelet aggregation, interferes with platelet activation, adhesion, and spreading. Mudanpioside C can be used for the research of cardiovascular diseases .

HY-124866

PDI-IN-3	PDI	Neurological Disease
PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .

HY-110172

PDI-IN-1	PDI	Cancer
PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 1.7 μM. PDI-IN-1 has anti-cancer activity.

HY-163351

PDI-IN-2	PDI	Cancer
PDI-IN-2 (Compound 22) is a PDI or recombinant *PDI* inhibitor with IC₅₀ values of 0.62 and 0.63 μM, respectively. PDI-IN-2 has antitumor activity .

HY-P11256

pDI	MDM-2/p53	Cancer
pDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC₅₀s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer .

HY-N19464

Dicentrinone	PDI	Inflammation/Immunology Cancer
Dicentrinone is an orally active *PDI* inhibitor with an IC₅₀ value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis .

HY-W851050A

BAP2	PDI	Neurological Disease Cancer
BAP2 is an allosteric protein disulfide isomerase (PDI) inhibitor with a IC₅₀ of 0.85 μM. BAP2 binds to His256 in the b′ domain of PDI and exerts inhibitory effects through allosteric binding to the b′ domain. BAP2 upregulates GRP78. BAP2 inhibits the growth of glioblastoma cells. BAP2 can be used in studies related to glioblastoma .

HY-100430R

CCF642 (Standard)	Apoptosis Reference Standards PDI	Cancer
CCF642 (Standard) is the analytical standard of CCF642 (HY-100430). This product is intended for research and analytical applications. CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-100432R

LOC14 (Standard)	PDI Reference Standards	Neurological Disease Inflammation/Immunology
LOC14 (Standard) is the analytical standard of LOC14 (HY-100432). This product is intended for research and analytical applications. LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-100433R

PACMA 31 (Standard)	PDI Reference Standards	Cancer
PACMA 31 (Standard) is the analytical standard of PACMA 31 (HY-100433). This product is intended for research and analytical applications. PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-P11256

pDI	MDM-2/p53	Cancer
pDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC₅₀s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer .

Bacitracin 3 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Source Classification Cancer	Environmental Pollutants Antibiotic Bacterial PDI
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

Mudanpioside C	Structural Classification Other Monoterpenes Monophenols other families Classification of Application Fields Terpenoids Other Diseases Phenols Plants Disease Research Fields Source Classification	PDI
Mudanpioside C is a protein disulfide isomerase (PDI) inhibitor with a human IC₅₀ of 3.31 μM and human K_d of 3.9 μM. Mudanpioside C suppresses collagen-induced platelet aggregation, interferes with platelet activation, adhesion, and spreading. Mudanpioside C can be used for the research of cardiovascular diseases .

Dicentrinone	Structural Classification Alkaloids Duguetia surinamensis R.E.Fr. Quinoline Alkaloids Plants Annonaceae Source Classification	PDI
Dicentrinone is an orally active *PDI* inhibitor with an IC₅₀ value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis .

Cat. No.	Product Name		Classification

HY-100433

PACMA 31 5 Publications Verification		Alkynes
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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