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Results for "

PrP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Apoptosis (1) Fluorescent Dye (3) PACAP Receptor (1) Parasite (1) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (3) Infection (6) Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107662

*TCS PrP* Inhibitor 13**	Apoptosis	Infection Cancer
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP ^C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC₅₀ value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .

HY-RS11219

PRPS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRPS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPS1 Human Pre-designed siRNA Set A PRPS1 Human Pre-designed siRNA Set A

HY-RS11220

PRPS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRPS2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPS2 Human Pre-designed siRNA Set A PRPS2 Human Pre-designed siRNA Set A

HY-100857

PrPSc-IN-1	Fluorescent Dye	Neurological Disease
PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP ^Sc, inhibits its accumulation, with an IC₅₀ of 1.6 μM. Anti-prion activity .

HY-136102

Py-ds-Prp-Osu

ADC Linker Cancer

Py-ds-Prp-Osu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
HY-P1511

PACAP-Related Peptide (PRP), human

PACAP Receptor Neurological Disease

PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.

*Py-ds-Prp-Osu*	ADC Linker	Cancer
Py-ds-Prp-Osu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

*PACAP-Related Peptide (PRP), human*	PACAP Receptor	Neurological Disease
PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.

HY-139201

Poly-D-lysine hydrobromide (MW 30000-70000)	Others	Cancer
Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrP ^C .

HY-139201A

Poly-D-lysine hydrobromide (MW 70000-150000)	Others	Cancer
Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 70000-150000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrP ^C .

HY-163341

PAR4 antagonist 1	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 1 (Compound 48) is a protease activated receptor 4 (PAR4) antagonist with an IC₅₀ of 1.8 nM. PAR4 antagonist 1 has an IC₅₀ of 2 nM against γ-thrombin-activated PAR4 in platelet-rich plasma (PRP). PAR4 antagonist 1 can be used in antithrombotic research .

HY-147702

BB 0305179	Others	Infection Neurological Disease
BB 0305179 (compound 59) is a potent anti-prion agent, with an IC₅₀ of 4.7 μM. BB 0305179 inhibits the toxicity of a specific PrP mutant carrying a deletion in the hydrophobic domain . BB 0305179 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P0019

Z-Gly-Gly-Arg-AMC	Fluorescent Dye	Cardiovascular Disease
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate 5+ Cited Publications	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-138865

BiCAPPA	Others	Infection
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrP ^Sc) from scrapie-infected cells, with an EC₅₀ of 0.32 μM .

HY-147371

Quinoprazine	Parasite	Infection Neurological Disease
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC₅₀ value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP ^{S ^c} levels ^- .

HY-128345

UDM-001651	Protease Activated Receptor (PAR)	Cardiovascular Disease
UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC₅₀=4 nM; K_d=1.4 nM). UDM-001651 shows antiplatelet potency (IC₅₀=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP) .

HY-D0939

Direct Blue 1 Chicago Sky Blue 6B
Direct Blue 1 (Chicago Sky Blue 6B) is a complex dye for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1 is a potent and competitive VGLUT inhibitor. Direct Blue 1 can inhibit the Aβ-binding small molecule PrP ligand. Direct Blue 1 has anti-inflammatory activity .

HY-128039

17-Phenyl-ω-trinor-PGE2	Prostaglandin Receptor	Others
17-Phenyl-ω-trinor-PGE2 is a PGE2 (HY-101952) analog, which is an agonist for EP1 and EP3 receptor. 17-Phenyl-ω-trinor-PGE2 inhibits the PAF-induced aggregation of human platelet-rich plasma (PRP) and Cicaprost (HY-19583) induced Cyclic AMP (HY-B1511) production .

Cat. No.	Product Name	Type

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate 5+ Cited Publications	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0019

Z-Gly-Gly-Arg-AMC

Chromogenic Substrates

Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

Z-Gly-Gly-Arg-AMC	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

Cat. No.	Product Name	Target	Research Area

HY-P0305

PrP (106-126) Prion protein (106-126)	Peptides	Infection
PrP (106-126) is a peptide corresponding to the prion protein (PrP) amyloidogenic region, and its biochemical properties resemble the infectious form of prion protein.

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate 5+ Cited Publications	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P1511

PACAP-Related Peptide (PRP), human

PACAP Receptor Neurological Disease

PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.

*PACAP-Related Peptide (PRP), human*	PACAP Receptor	Neurological Disease
PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.

HY-P0019

Z-Gly-Gly-Arg-AMC	Fluorescent Dye	Cardiovascular Disease
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

Cat. No.	Product Name	Target	Research Area

HY-P990167

*Anti-Mouse/Human PrP/prion protein Antibody (TW1)*	Inhibitory Antibodies	Others
Anti-Mouse/Human PrP/prion protein Antibody (TW1) is a mouse-derived IgG2a type antibody inhibitor, targeting to mouse/human PrP/prion protein.

HY-P990030

Ralzapastotug

AB-308
Inhibitory Antibodies Infection

Ralzapastotug (AB-308) is a monoclonal antibody targeting amino acids 106-126 of the cellular prion protein PrP ^C .

Ralzapastotug AB-308	Inhibitory Antibodies	Infection
Ralzapastotug (AB-308) is a monoclonal antibody targeting amino acids 106-126 of the cellular prion protein PrP ^C .

Species:	Human (2) Mouse (1)
Tag:	His (1) Fc (2)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71464

	Peroxiredoxin-2/PRDX2 Protein, Human (His) Epididymis secretory sperm binding protein Li 2a; HEL S 2a; MGC4104; Natural killer cell enhancing factor B; Natural killer cell-enhancing factor B; Natural Killer Enhancing Factor B; NKEF B; NKEF-B; NKEFB; Peroxiredoxin 2; Peroxiredoxin-2; PRDX 2; PRDX2; PrP; PRX2; PRXII; PTX1; TDPX1; Thiol Specific Antioxidant 1 ; Thiol specific antioxidant protein; Thiol-specific antioxidant protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Torin; TPX1; TSA	Human	E. coli
	Peroxiredoxin-2 (PRDX2) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides, which is essential for cellular protection against oxidative stress. It detoxifies peroxide, senses hydrogen peroxide-mediated signaling events, and may participate in signaling cascades initiated by growth factors and tumor necrosis factor-alpha. Peroxiredoxin-2/PRDX2 Protein, Human (His) is the recombinant human-derived Peroxiredoxin-2/PRDX2 protein, expressed by E. coli , with N-His labeled tag. The total length of Peroxiredoxin-2/PRDX2 Protein, Human (His) is 197 a.a., with molecular weight of ~25.8 kDa.

HY-P78023

	PRNP/CD230 Protein, Mouse (HEK293, Fc) Major prion protein; PrP; ALTPrP; PRIP; PrP; PRNP	Mouse	HEK293
	The PRNP/CD230 protein is involved in multiple cellular processes and may affect neuronal development, synaptic plasticity, and myelin maintenance. It promotes myelin homeostasis, induces apoptosis, and interacts with other proteins. PRNP/CD230 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PRNP/CD230 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PRNP/CD230 Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of 60-68 kDa.

HY-P74619

	PRNP/CD230 Protein, Human (HEK293, Fc) Major prion protein; CD230; ALTPrP; PRIP; PrP	Human	HEK293
	Although its primary function is unknown, the PRNP/CD230 protein has been implicated in multiple neuronal processes, including neuronal development, synaptic plasticity, and myelin homeostasis. PRNP acts as an agonist of the ADGRG6 receptor and promotes the maintenance of myelin. PRNP/CD230 Protein, Human (HEK293, Fc) is the recombinant human-derived PRNP/CD230 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PRNP/CD230 Protein, Human (HEK293, Fc) is 207 a.a., with molecular weight of ~57.4 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81840

Peroxiredoxin 2 Antibody (YA1585) PRDX2; NKEFB; TDPX1; Peroxiredoxin-2; Natural killer cell-enhancing factor B; NKEF-B; PrP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1	WB, IHC-P	Human, Mouse, Rat

HY-P82128

C4 Binding Protein Antibody (YA1873)

C4BP; C4BPB; PrP
WB, IHC-P, ICC/IF, IP Human, Rat
HY-P81980

Prion Protein Antibody (YA1725)

CJD; GSS; PrP; PRNP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; Prion protein; PrP27-30; PrP33-35C
WB, IHC-P Human, Mouse, Rat
HY-P82012

PRPF4 Antibody (YA1757)

PrP4; RP70; HPrP4; PrP4p; HPrP4P; SNRNP60
WB, IP Human, Mouse

HY-P83313

PRPF19 Antibody (YA3058) PrPF19; NMP200; PrP19; SNEV; Pre-mRNA-processing factor 19; Nuclear matrix protein 200; PrP19/PSO4 homolog; hPso4; Senescence evasion factor	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P82014

PRPF8 Antibody (YA1759)

HPrP8; p220; PrP8; PrPC8; PrPf8; RP13; SNRNP220
WB, IHC-P Human
HY-P82733

SF3A3 Antibody (YA2478)

splicing factor 3a subunit 3; PrP9; PrPF9; SAP61; SF3a60
WB Human, Mouse, Rat, Hamster
HY-P83423

CDC40 Antibody (YA3168)

cell division cycle 40; EH-binding protein 3; EHB3; pre-mRNA splicing factor 17; PrP17; PrPF17; Cdc40
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P82763

Calcineurin A Antibody (YA2508) PPP3CA; CALNA; CNA; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PrP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform	WB, ICC/IF, FC	Human, Mouse, Rat

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