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Results for "

Pyruvate+dehydrogenase+kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Cannabinoid Receptor (1) CD38 (1) Drug Derivative (1) Environmental Pollutants (1) HIF/HIF Prolyl-Hydroxylase (1) HSP (1) Interleukin Related (1) Neurokinin Receptor (1) NKCC (1) NO Synthase (1) PDHK (17) PDK-1 (2) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0445A

Sodium dichloroacetate Maximum Cited Publications 26 Publications Verification	PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis	Cancer
Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na ⁺-K ⁺-2Cl ⁻ cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .

HY-135954A

PDK4-IN-1 hydrochloride 3 Publications Verification	PDHK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity .

HY-16082

AZD7545 4 Publications Verification	PDHK	Metabolic Disease
AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC₅₀s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively .

HY-12492

VER-246608 4 Publications Verification	PDHK	Cancer
VER-246608 is a potent and ATP-competitive inhibitor of *pyruvate dehydrogenase kinase* (PDK) with IC₅₀s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively.

HY-135954

PDK4-IN-1 3 Publications Verification	PDHK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity .

HY-121744

PS10 5+ Cited Publications	PDHK	Inflammation/Immunology
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC₅₀ of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (K_d= 239 nM) than for Hsp90 (K_d= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy .PDK: pyruvate dehydrogenase kinase

HY-136882

TM-1	PDHK	Cancer
TM-1 is a potent inhibitor of *pyruvate dehydrogenase kinase* (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC₅₀s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation .

HY-W005629

Leelamine	Environmental Pollutants Cannabinoid Receptor PDK-1	Metabolic Disease Cancer
Leelamine is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor with an IC₅₀ value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells .

HY-128578

KPLH1130 2 Publications Verification	PDHK NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase	Metabolic Disease Inflammation/Immunology
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions .

HY-114702

M77976 2 Publications Verification	PDHK	Metabolic Disease
M77976 is a specific ATP-competitive inhibitor of *PDK4 (pyruvate dehydrogenase kinase* isoforms 4), with an IC₅₀** of 648 μM. M77976 is potential for the research of obesity and diabetes .

HY-149814

PDK-IN-1	PDHK HSP	Cancer
PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC₅₀ values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass .

HY-146552

PDHK-IN-4	PDHK	Metabolic Disease Cancer
PDHK-IN-4 (Compound 30) is a potent inhibitor of PDHK with IC₅₀s of 0.0051 and 0.0122 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-4 has the potential for the research of cancer diseases .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-157538

PDK4-IN-2	PDHK	Cardiovascular Disease
PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle .

HY-173298

PDHK1-IN-2	PDHK	Inflammation/Immunology Cancer
PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinases 1/2 (PDHK1/2), with an IC₅₀ of 0.007 μM for PDHK1 and an IC₅₀ of 0.015 μM for PDHK2. PDHK1-IN-2 can regulate immune cell metabolism and correct mitochondrial dysfunction, and is expected to be used in the research of autoimmune diseases, inflammatory diseases, cancers, and other conditions .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

HY-173581

Arachidonic acid leelamide	PDHK	Cancer
Arachidonic acid leelamide, a Leelamine (HY-W005629) analog, is a pyruvate dehydrogenase kinase (PDK) inhibitor. Arachidonic acid leelamide can be used for the study of breast cancer .

HY-146801

PDHK-IN-3	PDHK	Metabolic Disease Cancer
PDHK-IN-3 (compound 7) is a potent PDHK (pyruvate dehydrogenase kinase) inhibitor, with IC₅₀ values of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively .

HY-162586

PDHK-IN-7	PDHK	Cancer
PDHK-IN-7 (compound 32) is an inhibitor of pyruvate dehydrogenase kinase with an IC₅₀ value of 17 nM.PDHK-IN-7 activates PDH in rat livers and has a glucose-lowering effect in Zucker fatty rats .

HY-146554

PDHK-IN-5	PDHK	Cancer
PDHK-IN-5 (Compound 19) is a potent inhibitor of PDHK with IC₅₀s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases .

HY-176008

Lauric acid leelamide	Drug Derivative	Inflammation/Immunology
Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC₅₀ value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources .

Cat. No.	Product Name	Target	Research Area

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

Species:	Human (5) Mouse (2)
Tag:	His (7) GST (4)
Source:	sf9 insect cells (1) Sf9 insect cells (4) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71614

	PDK3 Protein, Mouse (His) Pdk3; Pyruvate dehydrogenase kinase isoform 3	Mouse	E. coli
	PDK3 is a metabolic regulator that inhibits pyruvate dehydrogenase through PDHA1 phosphorylation to fine-tune glucose metabolism and affect aerobic respiration. Phosphorylation of PDHA2 adds another layer of control. PDK3 Protein, Mouse (His) is the recombinant mouse-derived PDK3 protein, expressed by E. coli , with N-His labeled tag.

HY-P73718

	PDK1 Protein, Human (Inactive, sf9, His) Pyruvate dehydrogenase kinase isoform 1; PDK1; PDHK1	Human	Sf9 insect cells
	PDK1 protein is a key kinase that controls glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This molecular switch inhibits pyruvate dehydrogenase, fine-tunes metabolite flux and downregulates aerobic respiration. PDK1 Protein, Human (sf9, His) is the recombinant human-derived PDK1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P74639

	PDK4 Protein, Mouse (sf9, His-GST) Pyruvate dehydrogenase kinase isoform 4; PDK4; PDHK4	Mouse	Sf9 insect cells
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2.This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration.PDK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived PDK4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P705854

	PDK2 Protein, Human (sf9, His-GST) PDHK2; Pyruvate dehydrogenase kinase isoform 2 (PDH kinase 2; PDKII)	Human	sf9 insect cells

HY-P701737

	PDK4 Protein, Human (Active, GST) PDK4; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4; mitochondrial; Pyruvate dehydrogenase kinase isoform 4	Human	E. coli
	PDK4 Protein phosphorylates PDHA1 and PDHA2, inhibiting pyruvate dehydrogenase activity. This reduces glucose utilization, enhances fat metabolism, and helps maintain blood glucose levels during fasting. PDK4 also regulates fatty acid oxidation and biosynthesis, generates reactive oxygen species, protects epithelial cells, and regulates cell proliferation through metabolic regulation. PDK4 Protein, Human (GST) is the recombinant human-derived PDK4 protein, expressed by E. coli , with N-GST labeled tag.

HY-P705581

	PDK1 Protein, Human (Inactive, sf9, His-GST) Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1 ; PDHK1; EC:2.7.11.2	Human	Sf9 insect cells

HY-P706083

	PDK1 Protein, Human (Active, sf9, His) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDHK1	Human	Sf9 insect cells

HY-P704056

	PDK4 Protein, Mouse (221a.a, His) Pdk4; [Pyruvate dehydrogenase; acetyl-transferring)] kinase isozyme 4; mitochondrial; EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 4		E. coli
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2.This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration.PDK4 Protein, Mouse (221a.a, His )is the recombinant mouse-derived PDK4 protein, expressed by E. coli , with N-6*His tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2) human (1)
Application:	IHC-P (1) ICC/IF (2) IF-Tissue (1) IP (3) WB (3) FC (1) ELISA (1)
Isotype:	IgG (2) IgG1 (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (3)

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HY-P89698

	PDK4 Antibody (YA9042) Pyruvate dehydrogenase kinase isoform 4, Pdk4	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	PDK4 Antibody (YA9042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDK4.

HY-P81650

	PDK2 Antibody (YA1395) PDK2; PDHK2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; Pyruvate dehydrogenase kinase isoform 2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PDK2 Antibody (YA1395) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDK2.

HY-P85321

	PDK1 Antibody (YA5013) PDK1; PDHK1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; mitochondrial; Pyruvate dehydrogenase kinase isoform 1	WB, IP	Human, Mouse, Rat
	PDK1 Antibody (YA5013) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PDK1.

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