1. Metabolic Enzyme/Protease
  2. PDHK
  3. M77976

M77976 

Cat. No.: HY-114702
Handling Instructions

M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes.

For research use only. We do not sell to patients.

M77976 Chemical Structure

M77976 Chemical Structure

CAS No. : 394237-61-7

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Description

M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].

IC50 & Target

IC50: 648 μM (PDK4)[1]

In Vitro

M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid[1].
M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4[1].

Molecular Weight

296.32

Formula

C₁₇H₁₆N₂O₃

CAS No.

394237-61-7

SMILES

COC1=CC=C(C=C1)C2=C(NN=C2C3=CC=C(C=C3O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

M77976M 77976M-77976PDHKPyruvate dehydrogenase kinasePDH kinasePDK4pyruvatedehydrogenasekinaseobesitydiabetesInhibitorinhibitorinhibit

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M77976
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