394237-61-7
394237-61-7
Chemical Structure
M77976
- CAS No.: 394237-61-7
- Formula:C17H16N2O3
- Molecular Weight:296.32
IUPAC Name: 4-(4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl)benzene-1,3-diol
InChIKey: GSBFARPNIZUMHA-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=C(NN=C2C3=CC=C(C=C3O)O)C
Biological Activity: M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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M77976 | 99.44% | M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes. | ||||||||||||||||||||
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P18IN003 | 99.49% | P18IN003 is a potent p18(INK4C) inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC. | ||||||||||||||||||||
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HS-1793 | 99.26% | HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines. HS-1793 induces cell apoptosis. | ||||||||||||||||||||
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yGsy2p-IN-1 | 98.57% | yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs). | ||||||||||||||||||||
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Ferroptosis-IN-3 | Ferroptosis-IN-3 (Compound 25) is a ferroptosis inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC50: 8.6 nM in HT-1080 cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC50: 3.94 and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation. | |||||||||||||||||||||
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Antitumor agent-120 | 96.0% | Antitumor agent-120 (compound 1) is a flavonoid compound isolated from Kudzu root.Antitumor agent-120 has no significant inhibitory activity against LNCaP and PC3 cancer cells, with IC50s >50 μM. | ||||||||||||||||||||
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Antibacterial agent 241 | Antibacterial agent 241 is a histidine kinase (HK) inhibitor, with IC50 values of 14 μM and 238 μM for CckA and PhoQ, respectively. Antibacterial agent 241 shows moderate antibacterial activity against E. coli DC2, Bacillus cereus, and Bacillus subtilis, with a MIC range of 12-74 μg/mL. |
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FGFR1 inhibitor-17 | FGFR1 inhibitor-17 (Compound 92) is a potent FGFR1 inhibitor. FGFR1 inhibitor-17 is promising for research of cancers. | |||||||||||||||||||||
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Anitrazafen | Anitrazafen is a topically effective antiinflammatory agent. | |||||||||||||||||||||
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Anti-inflammatory agent 115 | Anti-inflammatory agent 115 is a potent anti-inflammatory agent. Anti-inflammatory agent 115 reduces secretion of myeloperoxidase (MPO), TNF-α, IL-1β, and IL-6. Anti-inflammatory agent 115 decreases ear tissue thickness and neutrophil infiltration in 12-O-tetradecanoylphorbol-13-acetate (TPA) (HY-18739)-induced topical edema in mice. Anti-inflammatory agent 115 can be used for the research of inflammatory diseases. | |||||||||||||||||||||
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1,4-Bis(3,5-dimethyl-1H-pyrazol-4-yl)benzene | 1,4-Bis(3,5-dimethyl-1H-pyrazol-4-yl)benzene (4,4''-(1,4-Phenylene)bis[3,5-dimethyl-1h-pyrazole) is a metal-organic framework (MOF). | |||||||||||||||||||||
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