Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25) is a ferroptosis inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC50: 8.6 nM in HT-1080 cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC50: 3.94 and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation.
For research use only. We do not sell to patients.
- CAS No.: 3017222-33-9
- Formula: C15H11ClN2O2
- Molecular Weight:286.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | EC50 |
89.7 nM
Compound: 25
|
Anti-ferroptotic activity against RSL3 induced ferroptosis in human 786-0 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
Anti-ferroptotic activity against RSL3 induced ferroptosis in human 786-0 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
|
[PMID: 37950965] |
| BJ | EC50 |
11.3 nM
Compound: 25
|
Anti-ferroptotic activity against RSL3 induced ferroptosis in human BJ cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
Anti-ferroptotic activity against RSL3 induced ferroptosis in human BJ cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
|
[PMID: 37950965] |
| H9c2 | EC50 |
43.3 nM
Compound: 25
|
Anti-ferroptotic activity against RSL3 induced ferroptosis in rat H9c2 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
Anti-ferroptotic activity against RSL3 induced ferroptosis in rat H9c2 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
|
[PMID: 37950965] |
| HT-1080 | EC50 |
48.3 nM
Compound: 25
|
Anti-ferroptotic activity against imidazole ketone erastin (IKE) induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
Anti-ferroptotic activity against imidazole ketone erastin (IKE) induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
|
[PMID: 37950965] |
| HT-1080 | EC50 |
8.6 nM
Compound: 25
|
Anti-ferroptotic activity against RSL3 induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
Anti-ferroptotic activity against RSL3 induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
|
[PMID: 37950965] |
| HT-1080 | EC50 |
8.6 nM
Compound: 25
|
Anti-ferroptotic activity in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
Anti-ferroptotic activity in human HT-1080 cells assessed as cell viability incubated for 24 hrs by Cell-titer-glo assay
|
[PMID: 37950965] |
Chemical Information
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CAS No. 3017222-33-9
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Molecular Weight 286.71
-
Formula C15H11ClN2O2
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SMILES
OC1=C(C2=CC=C(O)C=C2)NN=C1C3=CC=C(Cl)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)