2. Apoptosis
  3. Apoptosis
  4. HS-1793

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines. HS-1793 induces cell apoptosis.

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HS-1793 Chemical Structure

HS-1793 Chemical Structure

CAS No. : 927885-00-5

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Based on 1 publication(s) in Google Scholar

HS-1793 Related Antibodies

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Description

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines[1]. HS-1793 induces cell apoptosis[2].

In Vitro

HS-1793 (0-100 µM; 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells[1][2].
HS-1793 (0-50 µM; 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level[1].
HS-1793 (0-100 µM; 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HS-1793 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231 and MCF-10A
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed antiproliferation activity with IC50 values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively.

Western Blot Analysis[1]

Cell Line: MCF-7, MDA-MB-231
Concentration: 12.5, 25 and 50 μM
Incubation Time: 4 h
Result: Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines.

RT-PCR[1]

Cell Line: MCF-7, MDA-MB-231
Concentration: 12.5, 25 and 50 μM
Incubation Time: 4 h
Result: Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells.

Cell Proliferation Assay[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 1, 2 and 4 days
Result: Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116.

Apoptosis Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation.

Western Blot Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 24 h
Result: Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level.

Cell Cycle Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25 and 50 µM
Incubation Time: 24 h
Result: Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner.
In Vivo

HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1]
Dosage: 5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO))
Administration: Intraperitoneal injection, twice a week, 4 weeks
Result: Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues.
Molecular Weight

252.26

Formula

C16H12O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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HS-1793 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-1793927885-00-5HS1793HS 1793ApoptosisresveratrolMCF-7MDA-MB-231HIF-1αcolon cancerbreast cancerHCT116VEGFAktERKInhibitorinhibitorinhibit

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