2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related
  4. Anti-inflammatory agent 115

Anti-inflammatory agent 115 is a potent anti-inflammatory agent. Anti-inflammatory agent 115 reduces secretion of myeloperoxidase (MPO), TNF-α, IL-1β, and IL-6. Anti-inflammatory agent 115 decreases ear tissue thickness and neutrophil infiltration in 12-O-tetradecanoylphorbol-13-acetate (TPA) (HY-18739)-induced topical edema in mice. Anti-inflammatory agent 115 can be used for the research of inflammatory diseases.

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Anti-inflammatory agent 115

Anti-inflammatory agent 115 Chemical Structure

CAS No. : 1504587-21-6

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Anti-inflammatory agent 115 Related Antibodies

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Description

Anti-inflammatory agent 115 is a potent anti-inflammatory agent. Anti-inflammatory agent 115 reduces secretion of myeloperoxidase (MPO), TNF-α, IL-1β, and IL-6. Anti-inflammatory agent 115 decreases ear tissue thickness and neutrophil infiltration in 12-O-tetradecanoylphorbol-13-acetate (TPA) (HY-18739)-induced topical edema in mice. Anti-inflammatory agent 115 can be used for the research of inflammatory diseases[1].

IC50 & Target[1]

TNF-α

 

IL-6

 

IL-1β

 

In Vitro

Anti-inflammatory agent 115 (compound 3R) (10 μM; 1 h pre-incubation, 3 h LPS stimulation) potently reduces LPS-induced secretion of TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages[1].
Anti-inflammatory agent 115 binds to the catalytic domains of COX-1 and COX-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 115 Related Antibodies

Real Time qPCR[1]

Cell Line: RAW 264.7 macrophages
Concentration: 10 μM
Incubation Time: 1 h
Result: Halved LPS-induced TNF-α, IL-6, and IL-1β mRNA expression.
Showed similar activity to Celecoxib (HY-14398) in reducing cytokine mRNA levels.
In Vivo

Anti-inflammatory agent 115 (compound 3R) (0.1-1 μmol/ear; topical; single dose) exhibits potent anti-inflammatory activity in TPA induced edema in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice (male, 25-30 g) topically administered with ethanolic TPA (0.25 mg/mL) to the right ear to induce edema [1]
Dosage: 0.1; 0.31; 1 μmol/ear
Administration: topical; single dose
Result: Achieved 91% edema reduction at 1 μmol/ear.
Reached a median inhibition dose (ID50) of 0.56 μmol/ear.
Inhibited myeloperoxidase (MPO) activity by 98% at 1 μmol/ear.
Halved TPA-induced MPO activity at 0.1 μmol/ear.
Returned MPO activity to basal levels at 0.31 μmol/ear and 1 μmol/ear.
Reduced ear thickness and diminished neutrophil infiltration compared to TPA-only treated ears.
Molecular Weight

264.32

Formula

C17H16N2O
CAS No.
SMILES

COC1=CC=C(C2=C(C)NN=C2C3=CC=CC=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 115 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 1151504587-21-6TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILmyeloperoxidaseCOX-1TNF-αTPA-induced topical edemaArtemia salinaIL-1βRAW 264.7 macrophagesIL-6COX-2neutrophil infiltrationInhibitorinhibitorinhibit

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