1. Metabolic Enzyme/Protease
  2. PDHK
  3. KPLH1130

KPLH1130 

Cat. No.: HY-128578 Purity: 99.53%
Handling Instructions

KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice.

For research use only. We do not sell to patients.

KPLH1130 Chemical Structure

KPLH1130 Chemical Structure

CAS No. : 906669-07-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 467 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice[1].

IC50 & Target

PDK[1]

Molecular Weight

283.28

Formula

C₁₅H₁₃N₃O₃

CAS No.

906669-07-6

SMILES

OC1=CC=C(C2=NNC(N2C3=CC=C(C)C=C3)=O)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 135 mg/mL (476.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5301 mL 17.6504 mL 35.3008 mL
5 mM 0.7060 mL 3.5301 mL 7.0602 mL
10 mM 0.3530 mL 1.7650 mL 3.5301 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (7.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

KPLH1130KPLH 1130KPLH-1130PDHKPyruvate dehydrogenase kinasePDH kinaseInhibitorinhibitorinhibit

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Product name:
KPLH1130
Cat. No.:
HY-128578
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