906669-07-6
Chemical Structure
KPLH1130
- CAS No.: 906669-07-6
- Formula:C15H13N3O3
- Molecular Weight:283.28
IUPAC Name: 5-(2,4-dihydroxyphenyl)-4-(p-tolyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
InChIKey: UUTBMTOBGXJTLN-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=NNC(N2C3=CC=C(C)C=C3)=O)C(O)=C1
Biological Activity: KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KPLH1130 | 99.86% | KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions. | ||||||||||||||||||||
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Keywords
