2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. PDHK HSP
  4. PDK-IN-1

PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass.

For research use only. We do not sell to patients.

PDK-IN-1 Chemical Structure

PDK-IN-1 Chemical Structure

CAS No. : 2897696-10-3

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PDK-IN-1 Related Antibodies

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Description

PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass[1].

IC50 & Target

IC50: 0.03 ± 0.005 μM (PDK1); 0.1 μM (HSP90)[1]
In Vitro

PDK-IN-1 (compound 7o) shows 2D cytotoxic activity against PSN-1 and BxPC-3 pancreatic cell lines, with IC50 values of 0.1 ± 0.04 and 1.0 ± 0.2 μM, respectively. PDK-IN-1 also shows 3D cytotoxic activity, with IC50 values of 3.3 ± 0.2 and 11.9 ± 1.1 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDK-IN-1 Related Antibodies
In Vivo

PDK-IN-1 (compound 7o) is slightly more effective than cisplatin (HY-17394) in reducing the tumor mass[1].
PDK-IN-1 intensely reduces PDH phosphorylation in Lewis Lung Carcinoma (LLC)-bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LLC-bearing C57BL mice[1]
Dosage: 20 mg/kg
Administration: IP, daily, days 7-14
Result: Reduced more tumor mass than cisplatin (HY-17394) (tumor inhibition by 86 and 84% for compound 7o and cisplatin, respectively). Induced a body weight loss much lower than that induced by cisplatin (HY-17394) and gemcitabine (HY-17026).
Molecular Weight

450.29

Formula

C20H16BrN7O
CAS No.
SMILES

BrC1=CC(C(C2=C(C3=CNC4=C3C=C(OC)C=C4)N=NC(N)=N2)=CN5C)=C5N=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDK-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDK-IN-12897696-10-3PDHKHSPPyruvate dehydrogenase kinasePDH kinaseHeat shock proteinsPSN-1 cancer cellsBxPC-3Lewis Lung CarcinomaInhibitorinhibitorinhibit

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