2897696-10-3
2897696-10-3
Chemical Structure
PDK-IN-1
- CAS No.: 2897696-10-3
- Formula:C20H16BrN7O
- Molecular Weight:450.29
IUPAC Name: 5-(5-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-6-(5-methoxy-1H-indol-3-yl)-1,2,4-triazin-3-amine
InChIKey: GLYKHSDGYVKDPV-UHFFFAOYSA-N
SMILES: BrC1=CC(C(C2=C(C3=CNC4=C3C=C(OC)C=C4)N=NC(N)=N2)=CN5C)=C5N=C1
Biological Activity: PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass[1].
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PDK-IN-1 | 99.74% | PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass. | ||||||||||||||||||||
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