GZ-389988
Based on 1 Customer Validation
GZ-389988 is a potent pan-TRK inhibitor with IC50 values of 0.3, 0.1, and 0.5 nM for TRKA, TRKB, and TRKC, respectively. GZ-389988 can be used to study NTRK fusion-positive tumors.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 1788906-96-6
- Formula: C26H26N6O3
- Molecular Weight:470.52
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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TrkA 0.3 nM (IC50) |
TrkB 0.1 nM (IC50) |
TrkC 0.5 nM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1788906-96-6
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Appearance Solid
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Molecular Weight 470.52
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Formula C26H26N6O3
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Color Light yellow to light brown
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SMILES
NC1=NC2=CC(C3=CN(C)N=C3)=CN=C2N1CC4=CC=C(OCC5=CC=C(OC)C=C5)C(OC)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 40 mg/mL (85.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1253 mL | 10.6265 mL | 21.2531 mL | 53.1327 mL |
| 5 mM | 0.4251 mL | 2.1253 mL | 4.2506 mL | 10.6265 mL | |
| 10 mM | 0.2125 mL | 1.0627 mL | 2.1253 mL | 5.3133 mL | |
| 15 mM | 0.1417 mL | 0.7084 mL | 1.4169 mL | 3.5422 mL | |
| 20 mM | 0.1063 mL | 0.5313 mL | 1.0627 mL | 2.6566 mL | |
| 25 mM | 0.0850 mL | 0.4251 mL | 0.8501 mL | 2.1253 mL | |
| 30 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.7711 mL | |
| 40 mM | 0.0531 mL | 0.2657 mL | 0.5313 mL | 1.3283 mL | |
| 50 mM | 0.0425 mL | 0.2125 mL | 0.4251 mL | 1.0627 mL | |
| 60 mM | 0.0354 mL | 0.1771 mL | 0.3542 mL | 0.8855 mL | |
| 80 mM | 0.0266 mL | 0.1328 mL | 0.2657 mL | 0.6642 mL |
GZ-389988 Related Classifications
HY-120393 Related Classifications
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