2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 33

Tubulin inhibitor 33, a tubulin polymerization inhibitor, inhibits tubulin polymerization in a dose-dependent manner with an IC50 of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research.

For research use only. We do not sell to patients.

Tubulin inhibitor 33 Chemical Structure

Tubulin inhibitor 33 Chemical Structure

CAS No. : 2944462-67-1

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Tubulin inhibitor 33 Related Antibodies

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Description

Tubulin inhibitor 33, a tubulin polymerization inhibitor, inhibits tubulin polymerization in a dose-dependent manner with an IC50 of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research[1].

IC50 & Target

IC50: 9.05 μM (tubulin)[1]
In Vitro

Tubulin inhibitor 33 (Compound 3a) (0-5 nM; 24-48 hours) inhibits the proliferation, antimigratory and colony formation and induces G2/M arrest and apoptosis in HepG-2 cells[1].
Tubulin inhibitor 33 (0-5 nM; 12 hours) effectively inhibits tubulin polymerization in HepG-2 cells and disrupts microtubule dynamics
[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 33 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, HeLa, B16-F10, HepG-2 cells
Concentration: 0-5 nM
Incubation Time: 24-48 hours
Result: Exhibited the antiproliferative activity against the growth of cancer cells with an average IC50 value of 4.5 nM.
Suppressed the formation of HepG-2 colonies in a dose-dependent manner, with the colony-forming ability of HepG-2 cells being significantly suppressed.
Exhibited the antimigratory effects against HepG-2 cells.
Induced G2/M arrest and apoptosis in HepG-2 cells.

Immunofluorescence[1]

Cell Line: HepG-2 cells
Concentration: 0-5 nM
Incubation Time: 12 hours
Result: Effectively inhibited tubulin polymerization in vitro and disrupted microtubule dynamics.
In Vivo

Tubulin inhibitor 33 (Compound 3a) (5 mg/kg; i.p. everyday for 14 days) significantly inhibits melanoma tumor growth with tumor growth inhibition (TGI) of 62.96%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-F10 melanoma model in C57 mice[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Significantly inhibited melanoma tumor growth with a TGI of 62.96%.
Molecular Weight

414.46

Formula

C24H22N4O3
CAS No.
SMILES

COC1=C(OC)C(OC)=CC(C2=NC=CC3=C2N=C(C4=CC=CC5=C4C=CN5C)N3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 332944462-67-1Tubulin inhibitor33Tubulin inhibitor-33Microtubule/TubulinApoptosisIndole AnaloguesMelanomaAntitumorTubulin Polymerization InhibitorMCF-7HelaB16-F10Hepg-2Inhibitorinhibitorinhibit

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