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  5. Meridianin C

Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation.

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Meridianin C

Meridianin C Chemical Structure

CAS No. : 213473-00-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
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100 mg In-stock
250 mg In-stock
500 mg   Get quote  
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Meridianin C Related Antibodies

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Description

Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation[1].

Cellular Effect
Cell Line Type Value Description References
HEp-2 IC50
9.7 μM
Compound: Meridianin C
Inhibition of Hep-2 human larynx carcinoma cell proliferation
Inhibition of Hep-2 human larynx carcinoma cell proliferation
[PMID: 15026054]
HT-22 IC50
9.3 μM
Compound: 28
Antiproliferative activity against mouse HT22 cells by MTS reduction assay
Antiproliferative activity against mouse HT22 cells by MTS reduction assay
[PMID: 21623630]
HT-29 IC50
5.5 μM
Compound: Meridianin C
Inhibition of HT-29 colon carcinoma cell proliferation
Inhibition of HT-29 colon carcinoma cell proliferation
[PMID: 15026054]
HepG2 IC50
> 87 μM
Compound: 3
Cytotoxicity against human HepG2 cells after 48 hrs by Neutral Red assay
Cytotoxicity against human HepG2 cells after 48 hrs by Neutral Red assay
10.1039/C3MD00097D
IMR-32 IC50
> 25 μM
Compound: 28
Antiproliferative activity against human IMR32 cells by MTS reduction assay
Antiproliferative activity against human IMR32 cells by MTS reduction assay
[PMID: 21623630]
LLC-PK1 IC50
> 87 μM
Compound: 3
Cytotoxicity against a pig LLC-PK1 cells after 48 hrs by Neutral Red assay
Cytotoxicity against a pig LLC-PK1 cells after 48 hrs by Neutral Red assay
10.1039/C3MD00097D
LLC-PK1 IC50
> 87 μM
Compound: 3
Cytotoxicity against pig LLC-PK1 cells assessed as cell growth inhibition after 48 hrs by neutral red assay
Cytotoxicity against pig LLC-PK1 cells assessed as cell growth inhibition after 48 hrs by neutral red assay
[PMID: 26005918]
MCF7 IC50
24 μM
Compound: 28
Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test
Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test
[PMID: 21623630]
PTP IC50
23.9 μM
Compound: Meridianin C
Inhibition of PTP foreskin fibroblast cell proliferation
Inhibition of PTP foreskin fibroblast cell proliferation
[PMID: 15026054]
RD IC50
6.6 μM
Compound: Meridianin C
Inhibition of RD rhabdomyocarcinoma cell proliferation
Inhibition of RD rhabdomyocarcinoma cell proliferation
[PMID: 15026054]
SH-SY5Y IC50
> 25 μM
Compound: 28
Antiproliferative activity against human SH-SY5Y cells by MTS reduction assay
Antiproliferative activity against human SH-SY5Y cells by MTS reduction assay
[PMID: 21623630]
U-937 IC50
2.7 μM
Compound: Meridianin C
Inhibition of U937 cell proliferation
Inhibition of U937 cell proliferation
[PMID: 15026054]
Vero IC50
> 87 μM
Compound: 3
Cytotoxicity against african green monkey Vero cells after 48 hrs by Neutral Red assay
Cytotoxicity against african green monkey Vero cells after 48 hrs by Neutral Red assay
10.1039/C3MD00097D
Vero IC50
> 87 μM
Compound: 3
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red assay
[PMID: 26005918]
Molecular Weight

289.13

Formula

C12H9BrN4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=NC=CC(C2=CNC3=C2C=C(Br)C=C3)=N1
Structure Classification
Initial Source

marine
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (345.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4587 mL 17.2933 mL 34.5865 mL
5 mM 0.6917 mL 3.4587 mL 6.9173 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68%

SDS (393 KB)

COA (250 KB) HNMR (249 KB) LCMS (330 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4587 mL 17.2933 mL 34.5865 mL 86.4663 mL
5 mM 0.6917 mL 3.4587 mL 6.9173 mL 17.2933 mL
10 mM 0.3459 mL 1.7293 mL 3.4587 mL 8.6466 mL
15 mM 0.2306 mL 1.1529 mL 2.3058 mL 5.7644 mL
20 mM 0.1729 mL 0.8647 mL 1.7293 mL 4.3233 mL
25 mM 0.1383 mL 0.6917 mL 1.3835 mL 3.4587 mL
30 mM 0.1153 mL 0.5764 mL 1.1529 mL 2.8822 mL
40 mM 0.0865 mL 0.4323 mL 0.8647 mL 2.1617 mL
50 mM 0.0692 mL 0.3459 mL 0.6917 mL 1.7293 mL
60 mM 0.0576 mL 0.2882 mL 0.5764 mL 1.4411 mL
80 mM 0.0432 mL 0.2162 mL 0.4323 mL 1.0808 mL
100 mM 0.0346 mL 0.1729 mL 0.3459 mL 0.8647 mL
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Meridianin C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meridianin C213473-00-8OthersInhibitorinhibitorinhibit

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