213473-00-8
Chemical Structure
Meridianin C
- CAS No.: 213473-00-8
- Formula:C12H9BrN4
- Molecular Weight:289.13
IUPAC Name: 4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine
InChIKey: PKQJCYXKRNGUKQ-UHFFFAOYSA-N
SMILES: NC1=NC=CC(C2=CNC3=C2C=C(Br)C=C3)=N1
Biological Activity: Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Meridianin C | 99.26% | Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation. | ||||||||||||||||||||
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Keywords
