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Resolvin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Arrestin (1) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (2) CCR (1) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (9) ERK (1) GPR84 (1) Interleukin Related (3) Isotope-Labeled Compounds (5) Lipoxygenase (1) NF-κB (1) TNF Receptor (2) TRP Channel (5)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (27) Metabolic Disease (1) Neurological Disease (3)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114041

Resolvin E1 2 Publications Verification RvE1	Endogenous Metabolite	Inflammation/Immunology
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

HY-121636

Resolvin D2 5 Publications Verification RvD2	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC₅₀ = 0.1 nM) and TRPA1 (IC₅₀ = 2 nM) in primary sensory neurons .

HY-125527

Resolvin D1 1 Publications Verification RvD1	Endogenous Metabolite	Inflammation/Immunology
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-133159

Resolvin E2 (-)-Resolvin E2	Lipoxygenase	Inflammation/Immunology
Resolvin E2 ((-)-Resolvin E2), a proresolving lipid mediator, is useful as a lead for anti-inflammatory agent .

HY-17639

Navamepent RX-10045	Biochemical Assay Reagents	Inflammation/Immunology
Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114041S

Resolvin E1-d4 RvE1-d4	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin E1-d₄ (RvE1-d₄) is deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

HY-113533

Resolvin D4 RvD4	Bacterial	Inflammation/Immunology
Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection .

HY-125527A

*17(R)-Resolvin* D1** 1 Publications Verification 17(R)-RvD1; AT-RvD1	TRP Channel	Inflammation/Immunology
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-136540

Resolvin D3 RvD3	AMPK Autophagy	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-145491

Resolvin D5	ERK NF-κB CCR	Inflammation/Immunology
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .

HY-121636S

Resolvin D2-d5 RvD2-d₅	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC₅₀ = 0.1 nM) and TRPA1 (IC₅₀ = 2 nM) in primary sensory neurons .

HY-125527S

Resolvin D1-d5 RvD1-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-131993

Resolvin E4 RvE4	Endogenous Metabolite	Inflammation/Immunology
Resolvin E4 (RvE4) is an endogenous metabolite that stimulates efferocytosis of apoptotic neutrophils and senescent erythrocytes. Resolvin E4 enhances resolution of hemorrhagic exudates and inflammation in vivo .

HY-114041S1

Resolvin E1-d4-1 RvE1-d₄-1	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin E1-d₄-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

HY-128031

Resolvin D1 methyl ester RvD1 methyl ester	Drug Derivative	Metabolic Disease
Resolvin D1 methyl ester (RvD1 methyl ester) is the methyl ester of Resolvin D1 (HY-125527). Resolvin D1 methyl ester reduces triglyceride levels .

HY-172632

Resolvin D3 methyl ester	Endogenous Metabolite Interleukin Related	Inflammation/Immunology
Resolvin D3 methyl ester is a methyl ester version of Resolvin D3 that may act as a lipophilic prodrug form which can alter its distribution and pharmacokinetic properties. Resolvin D3 is a potent immunoresolvent. Resolvin D3 can reduce neutrophil infiltration in vivo. Resolvin D3 can be produced in murine inflammatory exudates and human macrophages. Resolvin D3 can activate the human RvD1 and RvD5. Resolvin D3 is a potent enhancer of the uptake of apoptotic neutrophils by macrophages as well as a stimulator of IL-10 .

HY-W708469

Resolvin D2 methyl ester	Endogenous Metabolite TRP Channel	Inflammation/Immunology
Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC₅₀=0.1 nM) and TRPA1 (IC₅₀=2 nM). Resolvin D2 can be used in sepsis research .

HY-136540S

Resolvin D3-d5 RvD3-d₅	Isotope-Labeled Compounds	Inflammation/Immunology
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-113533A

*17(R)-Resolvin* D4** 17(R)-RvD4	Bacterial	Inflammation/Immunology
17(R)-Resolvin D4 (17(R)-RvD4) is the R-enantiomer of Resolvin D4. Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection .

HY-139232

*17(R)-Resolvin* D3** 17(R)-RvD3	Drug Metabolite	Inflammation/Immunology
17(R)-Resolvin D3 is a metabolite of docosahexaenoic acid (DHA). 17(R)-Resolvin D3 has anti-inflammatory activity .

HY-168782

Resolvin D2 n-3 DPA	TNF Receptor Interleukin Related	Inflammation/Immunology
Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide .

HY-125527AS

*17(R)-Resolvin* D1-d5** 17(R)-RvD1-d₅; AT-RvD1-d₅	Isotope-Labeled Compounds TRP Channel	Inflammation/Immunology
17(R)-Resolvin D1-d₅ (17(R)-RvD1-d₅) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-155286

(7S,8R,17S)-RCTR1	Biochemical Assay Reagents	Infection Inflammation/Immunology
(7S,8R,17S)-RCTR1 is a specialized pro-resolving mediator, that exhibits anti-inflammatory and anti-infective activities. (7S,8R,17S)-RCTR1 promotes pathogen clearance, wound healing, tissue repair and regeneration .

HY-172750

*17(R,S)-Benzo-resolvin* D1** 17(R,S)-Benzo-RvD1	Drug Derivative	Inflammation/Immunology
17(R,S)-Benzo-resolvin D1 (17(R,S)-Benzo-RvD1) is a Resolvin D1 (HY-125527) analogue with pro-resolving and anti-migratory activity. 17(R,S)-Benzo-resolvin D1 attenuates neointimal hyperplasia in a rat model of acute vascular injury .

HY-125020

NCGC00135472	Arrestin	Inflammation/Immunology
NCGC00135472 is a potent agonist of resolvin D1 receptor (DRV1), with the EC₅₀ of 0.37 nM and 0.05 μM for β-arrestin and cAMP activities, respectively .

HY-167754

Resolvin D5 n-3 DPA	GPR84	Inflammation/Immunology
Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC₅₀s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation .

HY-145474

*17(R)-Resolvin* D1 methyl ester**	Endogenous Metabolite	Inflammation/Immunology
17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC₅₀ approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1 .

HY-180109

Benzo-17R-RvD2 Benzo-17R-Resolvin D2	TNF Receptor Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) is a benzo-containing analog of RvD2 (HY-121636). Benzo-17R-RvD2 enhances human macrophage efferocytosis, limits neutrophil infiltration, reduces TNF-α, and increases IL-1 receptor antagonist in peritonitis. Benzo-17R-RvD2 promotes E. coli killing by human leukocytes and reduces neutrophil swarm area without compromising anti-Candida activity. Benzo-17R-RvD2 activates the human-RvD2 receptor with an EC₅₀ ∼1.5 nM. Benzo-17R-RvD2 can be used in research on inflammation-associated diseases such as cardiovascular disease, cancer, neuroinflammation, pain, and muscle regeneration .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114041

Resolvin E1 2 Publications Verification RvE1	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

HY-125527

Resolvin D1 1 Publications Verification RvD1	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology Source Classification	Endogenous Metabolite
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-145491

Resolvin D5	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	ERK NF-κB CCR
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .

Cat. No.	Product Name	Chemical Structure

HY-114041S

Resolvin E1-d4
Resolvin E1-d₄ (RvE1-d₄) is deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

Resolvin E1-d4

Resolvin E1-d₄ (RvE1-d₄) is deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

HY-121636S

Resolvin D2-d5
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC₅₀ = 0.1 nM) and TRPA1 (IC₅₀ = 2 nM) in primary sensory neurons .

HY-125527S

Resolvin D1-d5
Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-114041S1

Resolvin E1-d4-1
Resolvin E1-d₄-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

Resolvin E1-d4-1

Resolvin E1-d₄-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .