1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Resolvin E1

Resolvin E1  (Synonyms: RvE1)

Cat. No.: HY-114041 Purity: ≥95.0%
COA Handling Instructions

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.

For research use only. We do not sell to patients.

Resolvin E1 Chemical Structure

Resolvin E1 Chemical Structure

CAS No. : 552830-51-0

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Solution
10 μg (285.3 μM * 100 μL in Ethanol) USD 370 In-stock
Estimated Time of Arrival: December 31
Solution
25 μg (285.3 μM * 250 μL in Ethanol) USD 740 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation with an EC50 of ∼1.0 nM in ChemR23-transfected cells. Resolvin E1 (100 nM) increases phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells[2]. Resolvin E1 specifically interacts with the LTB4 receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS (2,4,6-trinitrobenzene sulfonic acid) colitis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old female BALB/c mice (TNBS colitis model)[1]
Dosage: 1.0 μg per mouse; 50 μg/kg
Administration: i.p.; on days -8, -1, and 0 before the induction of colitis
Result: Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
Molecular Weight

350.45

Formula

C20H30O5

CAS No.
SMILES

CC[[email protected]@H](O)/C=C/C=C\C[[email protected]@H](O)/C=C/C=C/C=C\[[email protected]@H](O)CCCC(O)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Resolvin E1
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