1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Resolvin E1

Resolvin E1 (Synonyms: RvE1)

Cat. No.: HY-114041
Handling Instructions

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.

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Resolvin E1 Chemical Structure

Resolvin E1 Chemical Structure

CAS No. : 552830-51-0

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Description

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation with an EC50 of ∼1.0 nM in ChemR23-transfected cells. Resolvin E1 (100 nM) increases phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells[2]. Resolvin E1 specifically interacts with the LTB4 receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine[3].

In Vivo

Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS (2,4,6-trinitrobenzene sulfonic acid) colitis[1].

Animal Model: 6- to 8-week-old female BALB/c mice (TNBS colitis model)[1]
Dosage: 1.0 μg per mouse; 50 μg/kg
Administration: i.p.; on days -8, -1, and 0 before the induction of colitis
Result: Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
Molecular Weight

350.45

Formula

C₂₀H₃₀O₅

CAS No.

552830-51-0

SMILES

CC[[email protected]@H](O)/C=C/C=C\C[[email protected]@H](O)/C=C/C=C/C=C\[[email protected]@H](O)CCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Resolvin E1RvE1Resolvin E 1Resolvin E-1RvE 1RvE-1Endogenous Metaboliteendogenousmediatorinflammationcell-cellinteractionspolymorphonuclearleukocyteTNBScolitisInhibitorinhibitorinhibit

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Resolvin E1
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