2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related
  4. Benzo-17R-RvD2

Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) is a benzo-containing analog of RvD2 (HY-121636). Benzo-17R-RvD2 enhances human macrophage efferocytosis, limits neutrophil infiltration, reduces TNF-α, and increases IL-1 receptor antagonist in peritonitis. Benzo-17R-RvD2 promotes E. coli killing by human leukocytes and reduces neutrophil swarm area without compromising anti-Candida activity. Benzo-17R-RvD2 activates the human-RvD2 receptor with an EC50 ∼1.5 nM. Benzo-17R-RvD2 can be used in research on inflammation-associated diseases such as cardiovascular disease, cancer, neuroinflammation, pain, and muscle regeneration.

For research use only. We do not sell to patients.

Benzo-17R-RvD2

Benzo-17R-RvD2 Chemical Structure

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Benzo-17R-RvD2 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) is a benzo-containing analog of RvD2 (HY-121636). Benzo-17R-RvD2 enhances human macrophage efferocytosis, limits neutrophil infiltration, reduces TNF-α, and increases IL-1 receptor antagonist in peritonitis. Benzo-17R-RvD2 promotes E. coli killing by human leukocytes and reduces neutrophil swarm area without compromising anti-Candida activity. Benzo-17R-RvD2 activates the human-RvD2 receptor with an EC50 ∼1.5 nM. Benzo-17R-RvD2 can be used in research on inflammation-associated diseases such as cardiovascular disease, cancer, neuroinflammation, pain, and muscle regeneration[1].

IC50 & Target[1]

IL-1

 

human-RvD2 receptor

~1.5 nM (EC50)

Molecular Weight

374.47

Formula

C22H30O5
SMILES

CC/C=C\C[C@H]([C@@H](/C=C/C1=CC=CC=C1[C@H](C/C=C\CCC(O)=O)O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Benzo-17R-RvD2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzo-17R-RvD2Benzo-17R-Resolvin D2TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILhuman macrophage efferocytosisneutrophil swarmhuman-RvD2 receptorcardiovascular diseasecancerneuroinflammationpainmuscle regenerationInhibitorinhibitorinhibit

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