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Results for "

Retinoid+X+receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Autophagy (19) Drug Metabolite (1) Endogenous Metabolite (4) Environmental Pollutants (1) HCV (2) Isotope-Labeled Compounds (5) LXR (1) NO Synthase (1) RAR/RXR (33) Reactive Oxygen Species (ROS) (1) Reference Standards (8) SphK (2) VD/VDR (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (21) Infection (2) Inflammation/Immunology (1) Metabolic Disease (10) Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14171

Bexarotene Maximum Cited Publications 22 Publications Verification LGD1069	RAR/RXR Autophagy	Cancer
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-107500

UVI 3003 5+ Cited Publications	RAR/RXR Autophagy	Others
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC₅₀s of 0.22 and 0.24 μM, respectively.

HY-107399

CD3254 3 Publications Verification	RAR/RXR	Metabolic Disease Cancer
CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-15340

LG100268 5 Publications Verification LG268	RAR/RXR Autophagy	Metabolic Disease
LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC₅₀ values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the K_i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-A0067

Oxybenzone 5+ Cited Publications Benzophenone 3	Environmental Pollutants Autophagy RAR/RXR Apoptosis	Neurological Disease
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts *retinoid X receptor* signaling in apoptotic neuronal cells .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a *vitamin D receptor* (VDR)** agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-100008

Peretinoin 5+ Cited Publications NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and *retinoic acid receptor* (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV** RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-116506

Bigelovin	RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-153832

MSU-42011	RAR/RXR NO Synthase	Cancer
MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Endogenous Metabolite	Others
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-120875

HX600	RAR/RXR	Neurological Disease
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .

HY-14171S

Bexarotene-d4 LGD1069 d₄	RAR/RXR Autophagy	Cancer
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-A0067S

Oxybenzone-d5	RAR/RXR Apoptosis Autophagy	Neurological Disease
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-104070

LG-100064	RAR/RXR Autophagy	Cancer
LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-108525

Fluorobexarotene	RAR/RXR	Cancer
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a K_i value of 12 nM and an EC₅₀ value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .

HY-144377

RXR antagonist 1	RAR/RXR	Neurological Disease Metabolic Disease Cancer
RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA₂ of 8.06. RXR antagonist 1 can be used for type 2 diabetes research .

HY-155437

NEt-iFQ	RAR/RXR	Others
NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

HY-117376

(all-E)-UAB30 UAB30	RAR/RXR	Cancer
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC₅₀ of 34.7, 5.1, and 22.4 μM respectively .

HY-A0067R

Oxybenzone (Standard) Benzophenone 3 (Standard)	Reference Standards RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone (Standard) is the analytical standard of Oxybenzone. This product is intended for research and analytical applications. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts *retinoid X receptor* signaling in apoptotic neuronal cells .

HY-N2992

16α-Hydroxytrametenolic acid	RAR/RXR	Cancer
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-175480

RXR agonist 2	RAR/RXR	Neurological Disease Metabolic Disease
RXR agonist 2 (Compound 22) is a highly selective retinoid X receptor (RXR) agonist (EC₅₀=0.039 μM). RXR agonist 2 is promising for research of metabolic syndrome and Alzheimer's disease .

HY-177890

UAB116	LXR RAR/RXR Wnt β-catenin	Cancer
UAB116 is a *Liver X Receptor* (LXR)/Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin** pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells .

HY-117182

LG190178	Apoptosis VD/VDR RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer .

HY-14171S2

Bexarotene-13C6 LGD1069-¹³C₆	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-14171R

Bexarotene (Standard) LGD1069 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-A0067S1

Oxybenzone-13C6 Benzophenone 3-13C₆	Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W777169

Bexarotene-13C4 LGD1069-¹³C₄	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-W653958

Oxybenzone-d3 Benzophenone 3-d₃	Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone-d₃ (Benzophenone 3-d₃) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-15340R

LG100268 (Standard) LG268 (Standard)	RAR/RXR Autophagy Reference Standards	Metabolic Disease
LG100268 (Standard) is the analytical standard of LG100268. This product is intended for research and analytical applications. LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-100008R

Peretinoin (Standard) NIK333 (Standard)	Reference Standards RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].

HY-32350S1

Ercalcitriol-d3 1α,25-Dihydroxy Vitamin D2-d₃	Isotope-Labeled Compounds Endogenous Metabolite VD/VDR	Metabolic Disease
Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-107399R

CD3254 (Standard)	Reference Standards RAR/RXR	Metabolic Disease Cancer
CD3254 (Standard) is the analytical standard of CD3254 (HY-107399). This product is intended for research and analytical applications. CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-104070R

LG-100064 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
LG-100064 (Standard) is the analytical standard of LG-100064 (HY-104070). This product is intended for research and analytical applications. LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-N19756

Cochinchinone P	RAR/RXR	Cancer
Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research .

HY-107500R

UVI 3003 (Standard)	Reference Standards RAR/RXR Autophagy	Others
UVI 3003 (Standard) is the analytical standard of UVI 3003 (HY-107500). This product is intended for research and analytical applications. UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC₅₀s of 0.22 and 0.24 μM, respectively.

HY-180181

RXR antagonist 6	RAR/RXR	Metabolic Disease Cancer
RXR antagonist 6 (Compound 34) is a selective partial *retinoid X receptor* (RXR) antagonist. RXR antagonist 6 shows no agonistic activity for any of the human RXRα/β/γ subtypes but it can strongly inhibit the receptor activation induced by full agonists of RXR (such as Bezafibrate (HY-B0637)) with an IC₅₀ of 2.7 μM. RXR antagonist 6 can enhance PMA (HY-18739)-induced THP-1 cell differentiation. RXR antagonist 6 can be used for the research of cancer, metabolic and neurological disease, such as lymphoma .

HY-W107616R

3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)	Endogenous Metabolite Reference Standards	Others
3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard) is the analytical standard of 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (HY-W107616). This product is intended for research and analytical applications. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a *vitamin D receptor* (VDR)** agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-116506

Bigelovin	Classification of Application Fields Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer	RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Natural Products Rudbeckia laciniata L. Plants Compositae Source Classification	Endogenous Metabolite
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-N2992

16α-Hydroxytrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Cancer Source Classification	RAR/RXR
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-N19756

Cochinchinone P	Structural Classification Flavonoids Cratoxylum cochinchinense (Lour.) Blume Hypericaceae Plants Other Flavonoids Source Classification	RAR/RXR
Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research .

HY-W107616R

3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)	Structural Classification Natural Products Rudbeckia laciniata L. Plants Compositae Source Classification	Endogenous Metabolite Reference Standards
3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard) is the analytical standard of 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (HY-W107616). This product is intended for research and analytical applications. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

Cat. No.	Product Name	Chemical Structure

HY-14171S

Bexarotene-d4
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-A0067S

Oxybenzone-d5
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-14171S2

Bexarotene-13C6

Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-A0067S1

Oxybenzone-13C6

Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W777169

Bexarotene-13C4
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-W653958

Oxybenzone-d3

Oxybenzone-d₃ (Benzophenone 3-d₃) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-32350S1

Ercalcitriol-d3

Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

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