1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. Fluorobexarotene

Fluorobexarotene 

Cat. No.: HY-108525 Purity: >97.0%
Handling Instructions

Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.

For research use only. We do not sell to patients.

Fluorobexarotene Chemical Structure

Fluorobexarotene Chemical Structure

CAS No. : 1190848-23-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 451 In-stock
Estimated Time of Arrival: December 31
5 mg USD 560 Get quote
10 mg USD 950 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene[1].

IC50 & Target[1]

RXRα

12 nM (Ki)

RXRα

43 nM (EC50)

Molecular Weight

366.47

Formula

C₂₄H₂₇FO₂

CAS No.

1190848-23-7

SMILES

O=C(O)C1=CC=C(C(C2=C(C)C=C3C(C)(C)CCC(C)(C)C3=C2)=C)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 36 mg/mL (98.23 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7287 mL 13.6437 mL 27.2874 mL
5 mM 0.5457 mL 2.7287 mL 5.4575 mL
10 mM 0.2729 mL 1.3644 mL 2.7287 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >97.0%

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Keywords:

FluorobexaroteneRAR/RXRRetinoic acid receptorsRetinoid X receptorsrexinoidsapparentaffinityanalogInhibitorinhibitorinhibit

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Product name:
Fluorobexarotene
Cat. No.:
HY-108525
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