LG190178
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.
For research use only. We do not sell to patients.
- CAS No.: 233268-81-0
- Formula: C28H42O5
- Molecular Weight:458.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: 3a, LG190178, Diastereomeric mixture
|
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
|
[PMID: 23462715] |
| HL-60 | EC50 |
30 nM
Compound: 3a, LG190178, Diastereomeric mixture
|
Induction of monocytic cell differentiation in human HL60 cells
Induction of monocytic cell differentiation in human HL60 cells
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[PMID: 23462715] |
| HL-60 | ED50 |
44 nM
Compound: 7
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Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
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[PMID: 16019211] |
| LNCaP | EC50 |
20 nM
Compound: 3a, LG190178, Diastereomeric mixture
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Growth inhibition of human LNCAP cells
Growth inhibition of human LNCAP cells
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[PMID: 23462715] |
| SC-3 | IC50 |
19 nM
Compound: 7
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Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
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[PMID: 16019211] |
Chemical Information
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CAS No. 233268-81-0
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Molecular Weight 458.63
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Formula C28H42O5
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SMILES
OCC(O)COC1=CC=C(C(C2=CC=C(OCC(O)C(C)(C)C)C(C)=C2)(CC)CC)C=C1C
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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