(all-E)-UAB30
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively.
For research use only. We do not sell to patients.
- CAS No.: 205252-59-1
- Formula: C20H22O2
- Molecular Weight:294.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
>2000 nM
Compound: (all-E)-UAB30
|
Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha
Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha
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[PMID: 9572893] |
| CV-1 | EC50 |
110 nM
Compound: (all-E)-UAB30
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Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta
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[PMID: 9572893] |
| CV-1 | EC50 |
370 nM
Compound: (all-E)-UAB30
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Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR gamma
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR gamma
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[PMID: 9572893] |
| CV-1 | EC50 |
>2000 nM
Compound: (all-E)-UAB30
|
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha
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[PMID: 9572893] |
| HL-60 | ED50 |
>10000 nM
Compound: (all-E)-UAB30
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Induction of HL-60 cells differentiation over 4 days
Induction of HL-60 cells differentiation over 4 days
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[PMID: 9572893] |
| NB-4 | ED50 |
>10000 nM
Compound: (all-E)-UAB30
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Induction of NB4 cell differentiation
Induction of NB4 cell differentiation
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[PMID: 9572893] |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 205252-59-1
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Molecular Weight 294.39
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Formula C20H22O2
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SMILES
O=C(O)/C=C(C)/C=C/C=C(C)/C=C1CCCC2=C\1C=CC=C2
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Synonyms
UAB30
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(all-E)-UAB30 Related Classifications
HY-117376 Related Classifications
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