205252-59-1
205252-59-1
Chemical Structure
(all-E)-UAB30
Synonym(s): UAB30
- CAS No.: 205252-59-1
- Formula:C20H22O2
- Molecular Weight:294.39
IUPAC Name: (2E,4E,6E)-8-((E)-3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid
InChIKey: PPGNMFUMZSAZCW-FRCHHHHOSA-N
SMILES: O=C(O)/C=C(C)/C=C/C=C(C)/C=C1CCCC2=C\1C=CC=C2
Biological Activity: (all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively[1][2].
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(all-E)-UAB30 | (all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively. | |||||||||||||||||||||
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References
- [1]. Adele P. Williams, et al. UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts. Transl Oncol. 2019 Oct;12(10):1364-1374.
- [2]. Chu-Fang Chou, et al. The Retinoid X Receptor Agonist, 9-cis UAB30, Inhibits Cutaneous T-cell Lymphoma Proliferation Through the SKP2-p27kip1 Axis. J Dermatol Sci. 2018 Jun; 90(3): 343–356.
