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Results for "

Serine biosynthesis

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Peptides

1

MCE Kits

4

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101409
    O-Acetylserine

    O-Acetyl-L-Serine

    		 Endogenous Metabolite Infection
    O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.
    O-Acetylserine
  • HY-116073
    L-Penicillamine

    		Acyltransferase Infection Cancer
    L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss) .
    L-Penicillamine
  • HY-126254
    BI-4924
    1 Publications Verification

    		 Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h .
    BI-4924
  • HY-101409R
    O-Acetylserine (Standard)

    O-Acetyl-L-Serine (Standard)

    		 Reference Standards Endogenous Metabolite Infection
    O-Acetylserine (Standard) is the analytical standard of O-Acetylserine. This product is intended for research and analytical applications. O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.
    O-Acetylserine (Standard)
  • HY-W552257
    Hydroxypyruvic acid phosphate

    		Drug Intermediate Others
    Hydroxypyruvic acid phosphate serves as a crucial metabolic intermediate in the biosynthesis of L-Serine (HY-N0650), being formed from the conversion of the glycolytic intermediate 3-phosphoglycerate through the action of 3-phosphoglycerate dehydrogenase.
    Hydroxypyruvic acid phosphate
  • HY-134222AS
    N-Acetylserine-d3

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    N-Acetylserine-d3 is the deuterium labeled N-Acetylserine (HY-134222A). N-Acetylserine (N-Acetyl-L-serine) is a physiological inducer of cysteine biosynthesis and activator of CysB. N-Acetylserine can bind to the CysB apoprotein. N-Acetylserine stimulates cysJIH transcription in vitro. N-Acetylserine can be used in the research of SARS-CoV-2 infection .
    N-Acetylserine-d3
  • HY-N19420
    Theasinensin C

    		Renin Bacterial Interleukin Related TNF Receptor Cardiovascular Disease Inflammation/Immunology
    Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila-mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet .
    Theasinensin C
  • HY-180330
    Antimicrobial agent-46

    		Bacterial Infection
    Antimicrobial agent-46 is a inhibitor of Salmonella typhimurium serine acetyltransferase (StSAT) with an IC50 of 48.6 μM. Antimicrobial agent-46 inhibits bacterial growth in minimal medium lacking cysteine (LB 20%). Antimicrobial agent-46 exerts its effect by targeting the cysteine biosynthesis pathway, which is crucial for bacterial persistence and adaptability. Antimicrobial agent-46 exhibits antibacterial activity against the Gram-negative bacterium Escherichia coli. Antimicrobial agent-46 can be used in infection-related research .
    Antimicrobial agent-46
  • HY-101409S
    O-Acetylserine-13C

    O-Acetyl-L-Serine-13C

    		 Isotope-Labeled Compounds Endogenous Metabolite Infection
    O-Acetylserine- 13C (O-Acetyl-L-serine- 13C) is the 13C-labeled O-Acetylserine (HY-101409). O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants .
    O-Acetylserine-13C
  • HY-W552257A
    Hydroxypyruvic acid phosphate lithium

    		Drug Intermediate Others
    Hydroxypyruvic acid phosphate lithium serves as a crucial metabolic intermediate in the biosynthesis of L-Serine (HY-N0650), being formed from the conversion of the glycolytic intermediate 3-phosphoglycerate through the action of 3-phosphoglycerate dehydrogenase.
    Hydroxypyruvic acid phosphate lithium
  • HY-134222AR
    N-Acetylserine (Standard)

    N-Acetyl-L-Serine (Standard)

    		 Reference Standards Endogenous Metabolite Infection
    N-Acetylserine (Standard) is the analytical standard of N-Acetylserine (HY-134222A). This product is intended for research and analytical applications. N-Acetylserine (N-Acetyl-L-serine) is a physiological inducer of cysteine biosynthesis and activator of CysB. N-Acetylserine can bind to the CysB apoprotein. N-Acetylserine stimulates cysJIH transcription in vitro. N-Acetylserine can be used in the research of SARS-CoV-2 infection .
    N-Acetylserine (Standard)
  • HY-177092
    AGF347

    		Antifolate SHMT Apoptosis mTOR Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research .
    AGF347
  • HY-179652
    PHGDH-IN-6

    		Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    PHGDH-IN-6 (Compound L5) is a PHGDH allosteric inhibitor with an IC50 of 2.5 μM. PHGDH-IN-6 can be used for studying diseases related to serine synthesis .
    PHGDH-IN-6

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