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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
TRβ
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "TRβ" in MCE Product Catalog:
44
44 Publications Verification
Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3
44
44 Publications Verification
Synonyms: Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium
44
44 Publications Verification
Cat. No.: HY-A0070B
CAS No.: 345957-19-9
Synonyms: Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate
6
6 Cited Publications
NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively . NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models .
4
4 Cited Publications
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Research Areas:
TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
1
1 Cited Publications
Cat. No.: HY-A0070AG
CAS No.: 6893-02-3
Synonyms: Triiodothyronine (GMP); 3,3',5-Triiodo-L-thyronine (GMP); T3 (GMP)
1
1 Cited Publications
Cat. No.: HY-W011927S
CAS No.: 2483831-28-1
Synonyms: Bisphenol S (4,4'-Sulfonyldiphenol)-d8
Cat. No.: HY-W011927
CAS No.: 80-09-1
Synonyms: Bisphenol S; Bis(4-hydroxyphenyl) sulfone
Cat. No.: HY-A0070AR
CAS No.: 6893-02-3
Synonyms: Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)
Synonyms: KB2115
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Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research .
Cat. No.: HY-160207
CAS No.: 2156649-32-8
Synonyms: MA-JD21; ABX-002
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Elunetirom (MA-JD21 )is a TR-β selective CNS-penetrant TR-β agonist prodrug and can be used for study of major depressive disorder (MDD) .
Cat. No.: HY-127024
CAS No.: 251310-57-3
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Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα .
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VK-0214 is an agonist of the thyroid β receptor (TRβ). By activating the expression of ABCD2, it can reduce the accumulation of very long-chain fatty acids (VLCFAs) and further alleviate glioblastoma multiforme. VK-0214 has the effect of regulating fatty acid metabolism and can be used in the research of X-linked adrenoleukodystrophy (X-ALD) .
Cat. No.: HY-146997
CAS No.: 2770681-85-9
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TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH) .
Synonyms: Triiodothyronine sodium (Standard); 3,3',5-Triiodo-L-thyronine sodium (Standard); T3 sodium (Standard)
Category:
Cat. No.: HY-19513
CAS No.: 852947-39-8
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MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .
Cat. No.: HY-164495
CAS No.: 2128258-47-7
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Research Areas:
Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice .
Cat. No.: HY-A0070AS1
CAS No.: 1213569-04-0
Synonyms: Triiodothyronine-13C9,15N; 3,3',5-Triiodo-L-thyronine-13C9,15N; T3-13C9,15N
Cat. No.: HY-W011927R
CAS No.: 80-09-1
Synonyms: Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)
Synonyms: Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
