MLS000389544
MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2).
For research use only. We do not sell to patients.
- CAS No.: 573965-48-7
- Formula: C20H24N2O7S
- Molecular Weight:436.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
16.4 μM
Compound: 1, MSNB
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Cytotoxicity against human HepG2 cells after 72 hrs by luminescence analysis
Cytotoxicity against human HepG2 cells after 72 hrs by luminescence analysis
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[PMID: 22324546] |
Chemical Information
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CAS No. 573965-48-7
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Molecular Weight 436.48
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Formula C20H24N2O7S
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SMILES
O=C(OCC(NC1(C2)CC3CC2CC(C3)C1)=O)C4=CC=C(S(=O)(C)=O)C([N+]([O-])=O)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mire Zloh, et al. Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists. Life Sci. 2016 Feb 1:146:66-72. [Content Brief]
[2]. "Ronald L Johnson, et al. A Quantitative High-hroughput Screen Identifies ovel Inhibitors of the Interaction of hyroid eceptor β with a Peptide of Steroid eceptor oactivator 2. J Biomol Screen . 2011 Jul;16(6):618-27." [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLS000389544 Related Classifications
HY-125787 Related Classifications
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