573965-48-7
573965-48-7
Chemical Structure
MLS000389544
- CAS No.: 573965-48-7
- Formula:C20H24N2O7S
- Molecular Weight:436.48
IUPAC Name: 2-(adamantan-1-ylamino)-2-oxoethyl 4-(methylsulfonyl)-3-nitrobenzoate
InChIKey: BTXTVUJWNPMQBT-UHFFFAOYSA-N
SMILES: O=C(OCC(NC1(C2)CC3CC2CC(C3)C1)=O)C4=CC=C(S(=O)(C)=O)C([N+]([O-])=O)=C4
Biological Activity: MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2)[1][2].
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MLS000389544 | MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2). | |||||||||||||||||||||
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References
- [1]. Mire Zloh, et al. Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists. Life Sci. 2016 Feb 1:146:66-72. [Content Brief]
- [2]. "Ronald L Johnson, et al. A Quantitative High-hroughput Screen Identifies ovel Inhibitors of the Interaction of hyroid eceptor β with a Peptide of Steroid eceptor oactivator 2. J Biomol Screen . 2011 Jul;16(6):618-27." [Content Brief]
