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  2. Thyroid Hormone Receptor

Eprotirome (Synonyms: KB2115)

Cat. No.: HY-10473 Purity: >99.0%
Handling Instructions

Eprotirome is a liver-selective thyroid hormone receptor agonist.

For research use only. We do not sell to patients.

Eprotirome Chemical Structure

Eprotirome Chemical Structure

CAS No. : 355129-15-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1072 In-stock
Estimated Time of Arrival: December 31
1 mg USD 200 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Eprotirome is a liver-selective thyroid hormone receptor agonist.

IC50 & Target

Thyroid hormone receptor[1]

In Vivo

Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice[1].

Clinical Trial
References
Animal Administration
[1]

Twelve-week old male ob/ob mice are used in this study. A catheter is implanted into the right internal jugular vein before the hyperinsulinemic-euglycemic clamp. After recovery, mice are administered Eprotirome (0.3 mg/kg) via intraperitoneal injection for 10 days. On the day of the clamp experiment, conscious, overnight-fasted mice receive a primed (10 μCi) and constant rate intravenous infusion (0.1 μCi /min) of [3-3H] glucose to measure basal glucose turnover. After 60 to 75 minutes of labeled glucose infusion, the hyperinsulinemic-euglycemic clamp is performed with continuous infusion of insulin (12 mU/kg/min) and variable infusion of 25% glucose to maintain euglycemia (~120 mg/dL). Blood samples are collected by tail bleeding (approximately every 10 min) to measure blood glucose concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

487.14

Formula

C₁₈H₁₇Br₂NO₅

CAS No.

355129-15-6

SMILES

O=C(O)CC(NC1=CC(Br)=C(OC2=CC=C(O)C(C(C)C)=C2)C(Br)=C1)=O

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
Eprotirome
Cat. No.:
HY-10473
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Eprotirome

Cat. No.: HY-10473