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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
UCHL1
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "UCHL1" in MCE Product Catalog:
207
207 Publications Verification
Cat. No.: HY-16658
CAS No.: 187389-52-2
Synonyms: Z-Val-Ala-Asp(OMe)-FMK
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor [1]. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .
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20 Cited Publications
Cat. No.: HY-18637
CAS No.: 668467-91-2
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LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC50 of 25 μM.
4
4 Cited Publications
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6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer [1].
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1 Cited Publications
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IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells [1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis [1].
Cat. No.: HY-153627
Purity: ≥98.0%
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GK13S is a deubiquitinase UCHL1 ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells [1]. GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM [1].
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8RK64, a chemical probe, is a covalent UCHL1 inhibitor (IC50: 0.32 μM) [1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-178124
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Huib32 is a potent small-molecule inhibitor of USP32 (IC50 = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research [1].
Cat. No.: HY-161378
CAS No.: 3068994-24-8
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UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal Hydrolase L1 (UCHL1), with an IC50 of 5.1 μM. UCHL1-IN-1 can be used for cancer research [1].
Cat. No.: HY-D1726
CAS No.: 2705841-53-6
Cat. No.: HY-RS15400
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UCHL1 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-154914
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GK16S is a UCHL1 chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells [1]. GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-D2188
Cat. No.: HY-E70627
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Ubiquitin thiolesterase UCHL1 (EC 3.1.2.15) is a member of the ubiquitin carboxy-terminal hydrolase family of deubiquitinating enzymes. Ubiquitin thiolesterase UCHL1 functions as an ubiquitin ligase and a mono-ubiquitin stabilizer [1].
Cat. No.: HY-RS23182
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Uchl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uchl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16745
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Uchl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uchl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P991852
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Cat. No.: HY-P0110
CAS No.: 634911-81-2
Synonyms: (Iso)-Z-Val-Ala-Asp(OMe)-FMK
Cat. No.: HY-153627A
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GK13R is a low-activity enantiomer of GK13S (HY-153627). GK13R inhibits recombinant UCHL1 with an IC50 of ~2 μM. GK13R can be used for the study of glioblastoma [1].
Cat. No.: HY-P71096
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UCHL1; Ubiquitin C‑Terminal Hydrolase L1; PARK5; PGP9.5; Uch‑L1; UCHL‑1; Ubiquitin Carboxyl‑Terminal Esterase L1 (Ubiquitin Thiolesterase); Ubiquitin Carboxyl‑Terminal Hydrolase Isozyme L1; Neuron Cytoplasmic Protein 9.5; Ubiquitin Thioesterase L1; Ubiqui
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
