UCHL1

Isoforms Recommended:	UCHL1

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (1) Caspase (2) Deubiquitinase (14) Phosphatase (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (13) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	Azide (1) Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658

Z-VAD(OMe)-FMK Maximum Cited Publications 200 Publications Verification Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor ^[1]. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .

HY-18637

LDN-57444 15+ Cited Publications	Deubiquitinase Apoptosis	Neurological Disease
LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC₅₀ of 0.88 μM and a K_i of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC₅₀ of 25 μM.

HY-133118

6RK73 4 Publications Verification	Deubiquitinase	Cancer
6RK73 is a covalent irreversible and specific *UCHL1* inhibitor with an IC₅₀ of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC₅₀=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer ^[1].

HY-153627

GK13S	Deubiquitinase	Cancer
GK13S is a deubiquitinase *UCHL1* ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells ^[1]. GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138995

IMP-1710 1 Publications Verification	Deubiquitinase	Others
IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC₅₀ value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells ^[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis ^[1].

HY-12989

LDN-91946	Deubiquitinase	Neurological Disease Cancer
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a K_{i app} of 2.8 μM ^[1].

HY-148254

8RK64	Deubiquitinase	Cancer
8RK64, a chemical probe, is a covalent *UCHL1* inhibitor (IC₅₀: 0.32 μM) ^[1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-178124

Huib32	Deubiquitinase	Neurological Disease Cancer
Huib32 is a potent small-molecule inhibitor of USP32 (IC₅₀ = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research ^[1].

HY-161378

UCHL1-IN-1	Deubiquitinase	Cancer
UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal Hydrolase L1 (UCHL1), with an IC₅₀ of 5.1 μM. UCHL1-IN-1 can be used for cancer research ^[1].

HY-D1726

8RK59	Deubiquitinase	Cancer
8RK59, a Bodipy probe, is a potent *UCHL1* (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 ^[1].

HY-RS15400

UCHL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UCHL1 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UCHL1 Human Pre-designed siRNA Set A UCHL1 Human Pre-designed siRNA Set A

HY-154914

GK16S	Deubiquitinase	Others
GK16S is a *UCHL1* chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells ^[1]. GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-E70627

Ubiquitin thiolesterase UCHL1	Deubiquitinase	Neurological Disease
Ubiquitin thiolesterase UCHL1 (EC 3.1.2.15) is a member of the ubiquitin carboxy-terminal hydrolase family of deubiquitinating enzymes. Ubiquitin thiolesterase UCHL1 functions as an ubiquitin ligase and a mono-ubiquitin stabilizer ^[1].

HY-D2188

IMP-2373	Deubiquitinase	Cancer
IMP-2373 is a low-toxicity activity-based probe targeting covalent pan-deubiquitinase (DUB), which modulates and monitors DUB activity via covalent binding to the catalytic cysteine and active site of DUB. IMP-2373 enables real-time tracking of dynamic intracellular DUB activity in physiologically relevant living cell systems, and quantitative analysis of activity changes induced by pharmacological inhibition or MYC dysregulation. IMP-2373 can be used for research on related diseases such as B-cell lymphoma ^[1] .

HY-RS23182

Uchl1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Uchl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uchl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Uchl1 Rat Pre-designed siRNA Set A Uchl1 Rat Pre-designed siRNA Set A

HY-RS16745

Uchl1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Uchl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uchl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Uchl1 Mouse Pre-designed siRNA Set A Uchl1 Mouse Pre-designed siRNA Set A

HY-P991852

*Anti-CD45RO Antibody (UCHL-1)*	Phosphatase	Cancer
Anti-CD45RO Antibody (UCHL-1) reacts with the human CD45RO. CD45 is a glycoprotein member of the protein tyrosine phosphatase (PTP) family known for its involvement in regulating a variety of cellular processes. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) ^[1].

HY-P0110

(Iso)-Z-VAD(OMe)-FMK (Iso)-Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and *UCHL1* inhibitor Z-VAD(OMe)-FMK (HY-16658) ^[1].

HY-153627A

GK13R	Deubiquitinase	Neurological Disease Cancer
GK13R is a low-activity enantiomer of GK13S (HY-153627). GK13R inhibits recombinant UCHL1 with an IC₅₀ of ~2 μM. GK13R can be used for the study of glioblastoma ^[1].

HY-182636

MT16-001	Deubiquitinase Aldehyde Dehydrogenase (ALDH)	Metabolic Disease Inflammation/Immunology Cancer
MT16-001 is a cell-permeable *UCHL1* inhibitor with an IC₅₀ value of 580 nM. MT16-001 also exhibits considerable inhibitory activity against USP30, and shows selectivity for other UCH family deubiquitinases (DUBs) as well as the broader proteome. MT16-001 binds covalently to the cysteine residue at the active site of *UCHL1, and forms covalent interactions with ALDH2, ALDH9A1* and GATD3A in intact cells. Meanwhile, as a cytotoxic agent, it displays a steep dose-response curve in human embryonic kidney cells. MT16-001 can be used for research on various cancers, liver fibrosis and pulmonary fibrosis ^[1].

Cat. No.	Product Name	Type

HY-D1726

8RK59	Fluorescent Dyes
8RK59, a Bodipy probe, is a potent *UCHL1* (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 ^[1].

HY-D2188

IMP-2373	Fluorescent Dyes
IMP-2373 is a low-toxicity activity-based probe targeting covalent pan-deubiquitinase (DUB), which modulates and monitors DUB activity via covalent binding to the catalytic cysteine and active site of DUB. IMP-2373 enables real-time tracking of dynamic intracellular DUB activity in physiologically relevant living cell systems, and quantitative analysis of activity changes induced by pharmacological inhibition or MYC dysregulation. IMP-2373 can be used for research on related diseases such as B-cell lymphoma ^[1] .

IMP-2373

Fluorescent Dyes

IMP-2373 is a low-toxicity activity-based probe targeting covalent pan-deubiquitinase (DUB), which modulates and monitors DUB activity via covalent binding to the catalytic cysteine and active site of DUB. IMP-2373 enables real-time tracking of dynamic intracellular DUB activity in physiologically relevant living cell systems, and quantitative analysis of activity changes induced by pharmacological inhibition or MYC dysregulation. IMP-2373 can be used for research on related diseases such as B-cell lymphoma ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P0110

(Iso)-Z-VAD(OMe)-FMK (Iso)-Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and *UCHL1* inhibitor Z-VAD(OMe)-FMK (HY-16658) ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P991852

*Anti-CD45RO Antibody (UCHL-1)*	Phosphatase	Cancer
Anti-CD45RO Antibody (UCHL-1) reacts with the human CD45RO. CD45 is a glycoprotein member of the protein tyrosine phosphatase (PTP) family known for its involvement in regulating a variety of cellular processes. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) ^[1].

Recombinant Proteins Recommended:

UCH-L1

Species:	Human (1) Rat (1) Mouse (1)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73466

	UCHL1 Protein, Mouse (His) Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; UCHL1; PGP9.5	Mouse	E. coli
	UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes.It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases.UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience.UCHL1 Protein, Mouse (His) is the recombinant mouse-derived UCHL1 protein, expressed by E.coli , with N-His labeled tag.

HY-P71096

	UCHL1 Protein, Human (His, solution) Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1; UCH-L1; Neuron Cytoplasmic Protein 9.5; PGP 9.5; PGP9.5; Ubiquitin Thioesterase L1; UCHL1	Human	E. coli
	The UCHL1 protein is a multifunctional deubiquitinase that regulates a variety of cellular processes. It maintains synaptic and cardiac function, modulates inflammatory responses, and influences osteoclastogenesis. UCHL1 Protein, Human (His, solution) is the recombinant human-derived UCHL1 protein, expressed by E. coli, with C-His labeled tag.

HY-P74483

	UCHL1 Protein, Rat (His) Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; UCHL1; PGP9.5	Rat	E. coli
	The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins. As a thiol protease, it specifically cleaves the C-terminal glycine of ubiquitin. UCHL1 Protein, Rat (His) is the recombinant rat-derived UCHL1 protein, expressed by E. coli , with N-10*His labeled tag.

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Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (6) Rat (6) Mouse (6)
Application:	IHC-P (6) ICC/IF (5) IF-Tissue (1) IP (2) IHC-F (3) WB (6) FC (2) ELISA (3)
Isotype:	IgG (3) IgG1 (1) IgG2b (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86680

	PGP9.5 Antibody (YA6372) Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Park5; Parkinson Disease 5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase(neuron specific); Ubiquitin C terminal hydrolase; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH L1; UCH-L1; UCHL1; UCHL1_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	PGP9.5 Antibody (YA6372) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGP9.5.

HY-P80785

	PGP9.5 Antibody (YA231) UCHL1 / PGP9.5; UCHL1; B220; CD 45; CD45; cd45 antigen; ec3.1.3.48; GP 180; GP180; Human homolog of severe combined immunodeficiency due to PTPRC deficiency; L CA; L-CA; lca; Leukocyte common antigen; LY 5; LY5; Protein tyrosine phosphatase receptor type	WB, IHC-P, IHC-F, ICC/IF, IP	Human, Mouse, Rat
	PGP9.5 Antibody (YA231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGP9.5.

HY-P80785A

	PGP9.5 Antibody (YA231)(PBS only) UCHL1 / PGP9.5; UCHL1; B220; CD 45; CD45; cd45 antigen; ec3.1.3.48; GP 180; GP180; Human homolog of severe combined immunodeficiency due to PTPRC deficiency; L CA; L-CA; lca; Leukocyte common antigen; LY 5; LY5; Protein tyrosine phosphatase receptor type	WB, IHC-P, IHC-F, ICC/IF, IP	Human, Mouse, Rat
	PGP9.5 Antibody (YA231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGP9.5.

HY-P85926

	PGP9.5 Antibody (YA5618) Epididymis luminal protein 117; Epididymis secretory protein Li 53; HEL 117; HEL S 53; NDGOA; Neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; Park 5; PARK5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase; Ubiquitin C terminal hydrolase L1; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH-L1; UCHL1; UCHL1_HUMAN	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	PGP9.5 Antibody (YA5618) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGP9.5.

HY-P84038

	PGP9.5 Antibody (YA3735) NDGOA; PARK5; PGP95; SPG79; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	PGP9.5 Antibody (YA3735) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PGP9.5.

HY-P84038A

	PGP9.5 Antibody (YA3735)(PBS only) NDGOA; PARK5; PGP95; SPG79; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	PGP9.5 Antibody (YA3735) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PGP9.5.

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Cat. No.	Product Name		Classification

HY-153627

GK13S		Alkynes
GK13S is a deubiquitinase *UCHL1* ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells ^[1]. GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138995

IMP-1710 1 Publications Verification		Alkynes
IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC₅₀ value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells ^[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis ^[1].

HY-148254

8RK64		Azide
8RK64, a chemical probe, is a covalent *UCHL1* inhibitor (IC₅₀: 0.32 μM) ^[1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154914

GK16S		Alkynes
GK16S is a *UCHL1* chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells ^[1]. GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS15400

UCHL1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
UCHL1 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23182

Uchl1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Uchl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uchl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16745

Uchl1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Uchl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uchl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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