1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. LDN-91946

LDN-91946 

Cat. No.: HY-12989
Handling Instructions

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM.

For research use only. We do not sell to patients.

LDN-91946 Chemical Structure

LDN-91946 Chemical Structure

CAS No. : 439946-22-2

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Description

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].

IC50 & Target

Ki app: 2.8 μM (UCH-L1)[1]

In Vitro

LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM[1].
There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].

Molecular Weight

314.32

Formula

C₁₅H₁₀N₂O₄S

CAS No.

439946-22-2

SMILES

OC(C1=CC2=C(SC(C(C3=CC=CC=C3)=O)=C2N)NC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LDN-91946LDN91946LDN 91946DeubiquitinaseDUBsUbiquitinUCH-L1selectiveInhibitorinhibitorinhibit

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