W2 | MedChemExpress (MCE) Life Science Reagents

By Targets:	Dihydroorotate Dehydrogenase (1) Endogenous Metabolite (2) HCV (1) HIV (2) Isotope-Labeled Compounds (1) NF-κB (1) Parasite (13) SARS-CoV (3) TRP Channel (2)
By Research Areas:	Infection (13) Metabolic Disease (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010248

2-Phenylglycine DL-α-Phenylglycine	Endogenous Metabolite	Metabolic Disease
2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period .

HY-10852

Arterolane

OZ 277; RBx 11160
Parasite Infection

Arterolane is an antimalarial agent, with IC₅₀ of both 1.1 nM against P. falciparum Ro73 and W2, respectively.

Arterolane OZ 277; RBx 11160	Parasite	Infection
Arterolane is an antimalarial agent, with IC₅₀ of both 1.1 nM against P. falciparum Ro73 and W2, respectively.

HY-149642

hDHODH-IN-13	Dihydroorotate Dehydrogenase	Others
hDHODH-IN-13 (compound w2) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC₅₀ value of 173.4 nM. hDHODH-IN-13 can be used in the research of IBD .

HY-N4039

Homaloside D

Parasite Infection

Homaloside D is an antiplasmodial agent with an IC₅₀ of 20 μM (11 μg/mL) against Plasmodium falciparum,W₂ .

Homaloside D	Parasite	Infection
Homaloside D is an antiplasmodial agent with an IC₅₀ of 20 μM (11 μg/mL) against Plasmodium falciparum,W₂ .

HY-N3283

6-Methylhydroxyangolensate	Parasite	Infection
6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC₅₀ of 21.59 μg/ml against P. falciparum (W2/Indochina clone) .

HY-N11031

Z-Antiepilepsirine	Parasite	Infection
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-15975

GNF179	Parasite	Infection
GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC₅₀ of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active .

HY-W010248S

2-Phenylglycine-d5 DL-α-Phenylglycine-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
2-Phenylglycine-d₅ is the deuterium labeled 2-Phenylglycine. 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period[1].

HY-15980

GNF179 (Metabolite)	Parasite	Infection
GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.

HY-149937

Antimalarial agent 24	Parasite	Infection
Antimalarial agent 24 (Compound 7) is an antimalarial agent in vitro. Antimalarial agent 24 inhibits P. falciparum W2 strain with an IC₅₀ of 0.81 μM. Antimalarial agent 24 displays a CC₅₀ higher than 200 μM against HepG2 cells .

HY-120104

Nitidanin (±)-Nitidanin	Parasite HCV	Infection
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection ^[2].

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Infection
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum ^[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-135855

SARS-CoV-IN-1 1 Publications Verification	SARS-CoV Parasite	Infection
SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC₅₀ of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 15.4 and 133.2 nM; and IC₉₀s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities .

HY-135858

SARS-CoV-IN-3 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 μM in MT-4 cells .

HY-135856

SARS-CoV-IN-2 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .

HY-P1175

L-R4W2

TRP Channel Neurological Disease

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic ^[2].

L-R4W2	TRP Channel	Neurological Disease
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic ^[2].

HY-P1175A

L-R4W2 TFA	TRP Channel	Neurological Disease
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic ^[2].

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P1175

L-R4W2

TRP Channel Neurological Disease

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic ^[2].

L-R4W2	TRP Channel	Neurological Disease
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic ^[2].

HY-P1175A

L-R4W2 TFA	TRP Channel	Neurological Disease
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010248

2-Phenylglycine DL-α-Phenylglycine	Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period .

HY-N4039

Homaloside D	Structural Classification Monophenols Source classification Phenols Plants Homalium ceylanicum (Gardn.) Benth. Salicaceae	Parasite
Homaloside D is an antiplasmodial agent with an IC₅₀ of 20 μM (11 μg/mL) against Plasmodium falciparum,W₂ .

HY-N3283

6-Methylhydroxyangolensate	Khaya grandifoliola C. DC. Structural Classification Natural Products Source classification Plants Meliaceae	Parasite
6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC₅₀ of 21.59 μg/ml against P. falciparum (W2/Indochina clone) .

HY-N11031

Z-Antiepilepsirine	Structural Classification Alkaloids Piperidine Alkaloids Piper capense Source classification Piperaceae Plants	Parasite
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-120104

Nitidanin (±)-Nitidanin	Structural Classification Buxaceae Source classification Lignans Phenylpropanoids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Parasite HCV
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection ^[2].

HY-N6009

8-Deoxygartanin	Infection other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Parasite NF-κB
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum ^[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

Cat. No.	Compare	Product Name	Species	Source

HY-P700393

	BZW2 Protein, Human (GST) BZW2; basic leucine zipper and W2 domains 2; basic leucine zipper and W2 domain-containing protein 2; HSPC028; MST017; MSTP017	Human	E. coli
	BZW2 is a translation initiation regulator that inhibits non-AUG and RAN-initiated translation. As a competitive inhibitor of EIF5, it improves initiation accuracy by preventing EIF5-dependent translation of non-AUG codons. BZW2 Protein, Human (GST) is the recombinant human-derived BZW2 protein, expressed by E. coli , with N-GST labeled tag. The total length of BZW2 Protein, Human (GST) is 419 a.a., with molecular weight of 75.2 kDa.


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HY-W010248S

2-Phenylglycine-d5
2-Phenylglycine-d₅ is the deuterium labeled 2-Phenylglycine. 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period[1].

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