1. Anti-infection
  2. SARS-CoV
    Parasite
    HIV
  3. SARS-CoV-IN-2

SARS-CoV-IN-2 

Cat. No.: HY-135856 Purity: 98.66%
Handling Instructions

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities.

For research use only. We do not sell to patients.

SARS-CoV-IN-2 Chemical Structure

SARS-CoV-IN-2 Chemical Structure

CAS No. : 888958-26-7

Size Price Stock Quantity
5 mg USD 680 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities[1].

IC50 & Target

EC50: 1.9 μM (SARS-CoV, in Vero cells)[1]
IC50: 21.5 nM (3D7 P. falciparum), 30 nM (W2 P. falciparum)[1]
IC90: 51.0 nM (3D7 P. falciparum), 99.9 nM (W2 P. falciparum)[1]

In Vitro

SARS-CoV-IN-2 (Compound 3) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

455.72

Formula

C₂₄H₁₈ClFeN₃O

CAS No.

888958-26-7

SMILES

CN(CCO)CC12=C3[Fe+2]1456789([C-]%10C6=C7C8=C9%10)[C-]2(C4=C53)CNC%11=CC=NC%12=C%11C=CC(Cl)=C%12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 19.23 mg/mL (42.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1943 mL 10.9716 mL 21.9433 mL
5 mM 0.4389 mL 2.1943 mL 4.3887 mL
10 mM 0.2194 mL 1.0972 mL 2.1943 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.92 mg/mL (4.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SARS-CoV-IN-2SARS-CoVParasiteHIVSARS coronavirusHuman immunodeficiency virusanti-CoronavirusVeroP. falciparumHIV-1MT-4cellInhibitorinhibitorinhibit

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