Nitidanin
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection.
For research use only. We do not sell to patients.
- CAS No.: 171674-89-8
- Formula: C21H24O8
- Molecular Weight:404.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh7.5.1 | CC50 |
464.4 μM
Compound: 21
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Cytotoxicity against human Huh7.5.1 cells after 72 hrs by ATPlite assay
Cytotoxicity against human Huh7.5.1 cells after 72 hrs by ATPlite assay
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[PMID: 30485098] |
| KB | ED50 |
>99 μM
Compound: 4
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Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
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[PMID: 16562832] |
In Vitro
Nitidanin shows inhibitory effects to D6 and W2 clones of Plasmodium falciparum with IC50 values of 21.2 and 18.4 μM, respectively[1]. Nitidanin shows noncytotoxic effects to human oral epidermoid carcinoma (KB) cells with an EC50 value ＞99 μM[1]. Nitidanin shows low cytotoxic effect to human hepatoma Huh7.5.1 cells with an CC50 value of 464.4 μM[2]. Nitidanin (0-250 μM; 5 hours) shows anti-HCV activity with an IC50 value of 200 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 171674-89-8
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Molecular Weight 404.41
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Formula C21H24O8
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SMILES
OC[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2O[C@H]1C3=CC(OC)=C(O)C(OC)=C3
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Synonyms
(±)-Nitidanin
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50. [Content Brief]
[2]. Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nitidanin Related Classifications
HY-120104 Related Classifications
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