Nitidanin  (Synonyms: (±)-Nitidanin)

Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection^[1][2].

Nitidanin shows inhibitory effects to D6 and W2 clones of Plasmodium falciparum with IC₅₀ values of 21.2 and 18.4 μM, respectively^[1].
Nitidanin shows noncytotoxic effects to human oral epidermoid carcinoma (KB) cells with an EC₅₀ value ＞99 μM^[1].
Nitidanin shows low cytotoxic effect to human hepatoma Huh7.5.1 cells with an CC₅₀ value of 464.4 μM^[2].
Nitidanin (0-250 μM; 5 hours) shows anti-HCV activity with an IC₅₀ value of 200 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

404.41

C₂₁H₂₄O₈

171674-89-8

OC[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2O[C@H]1C3=CC(OC)=C(O)C(OC)=C3

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• [1]. Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50.  [Content Brief]

  [2]. Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637.  [Content Brief]