1. Anti-infection
  2. SARS-CoV
    Parasite
  3. SARS-CoV-IN-1

SARS-CoV-IN-1 

Cat. No.: HY-135855 Purity: 99.88%
Handling Instructions

SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities.

For research use only. We do not sell to patients.

SARS-CoV-IN-1 Chemical Structure

SARS-CoV-IN-1 Chemical Structure

CAS No. : 888958-25-6

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Description

SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities[1].

IC50 & Target

EC50: 4.9 μM (SARS-CoV, in Vero cells)[1]
IC50: 15.4 nM (3D7 P. falciparum), 133.2 nM (W2 P. falciparum)[1]
IC90: 25.7 nM (3D7 P. falciparum), 459.1 nM (W2 P. falciparum)[1]

In Vitro

SARS-CoV-IN-1 (Compound 2) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].

Molecular Weight

441.69

Formula

C₂₃H₁₆ClFeN₃O

CAS No.

888958-25-6

SMILES

ClC1=CC2=C(C=C1)C(NC[C-]34[Fe+2]56789%10%11([C-]%12C8=C9C%10=C%11%12)C3(CNCCO)=C5C6=C47)=CC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (94.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2640 mL 11.3202 mL 22.6403 mL
5 mM 0.4528 mL 2.2640 mL 4.5281 mL
10 mM 0.2264 mL 1.1320 mL 2.2640 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.17 mg/mL (9.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.17 mg/mL (9.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SARS-CoV-IN-1SARS-CoVParasiteSARS coronavirusanti-CoronavirusVeroP. falciparumMT-4cellInhibitorinhibitorinhibit

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