1. Anti-infection
  2. Parasite
  3. Arterolane

Arterolane (Synonyms: OZ 277; RBx 11160)

Cat. No.: HY-10852
Handling Instructions

Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.

For research use only. We do not sell to patients.

Arterolane Chemical Structure

Arterolane Chemical Structure

CAS No. : 664338-39-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.

IC50 & Target

IC50: 1.1 nM (P. falciparum Ro73), 1.1 nM (P. falciparum W2)[1]

In Vitro

Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively[1].

Clinical Trial
Storage

-20°C, protect from light, stored under argon

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5476 mL 12.7379 mL 25.4758 mL
5 mM 0.5095 mL 2.5476 mL 5.0952 mL
10 mM 0.2548 mL 1.2738 mL 2.5476 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (4.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (4.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (4.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

392.53

Formula

C₂₂H₃₆N₂O₄

CAS No.

664338-39-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Arterolane
Cat. No.:
HY-10852
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Arterolane

Cat. No.: HY-10852