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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
alpha helix
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "alpha helix" in MCE Product Catalog:
9
9 Publications Verification
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BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC) . BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM .
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9 Publications Verification
Cat. No.: HY-P80704
Synonyms: HIF1A; BHLHE78; MOP1; PASD8; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS doma
4
4 Cited Publications
Cat. No.: HY-P74888
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HIF1A; Basic-helix-Loop-helix-PAS Protein MOP1; Hypoxia Inducible Factor 1 Subunit alpha; HIF-1-alpha; BHLHe78; Hypoxia Inducible Factor 1 alpha Subunit; PASD8; Hypoxia-Inducible Factor1alpha; MOP1; Member Of PAS Superfamily 1; Class E Basic helix-Loop-He
1
Cat. No.: HY-P5423
CAS No.: 107658-43-5
Cat. No.: HY-P0311
CAS No.: 184776-51-0
Cat. No.: HY-P5960
Synonyms: PTBP1 α3-helix derived peptide P6 TFA
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Cat. No.: HY-P5726
CAS No.: 302343-01-7
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Cat. No.: HY-P0311A
Cat. No.: HY-W006886
CAS No.: 945212-26-0
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Cat. No.: HY-W028350
CAS No.: 40106-12-5
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NSC727447 is a vinyl urea-based allosteric inhibitor of HIV reverse transcriptase-associated RNase H with IC50 values of 2.0 μM and 2.5 μM against HIV-1 and HIV-2 RNase H, respectively, and IC50 values of 100 μM and 10.6 μM against Escherichia coli and human RNase H, respectively. NSC727447 exerts allosteric inhibitory effects mainly by interacting with the region adjacent to α-helix I in the thumb subdomain of the p51 subunit of HIV-1 reverse transcriptase. Cys280, Lys281 and the RNase H primer grip region are involved in its action, and it may inhibit the catalytic activity of RNase H by altering the positioning of nucleic acid substrates or the geometry of the RNase H active site. NSC727447 can be used in studies related to HIV infection, the function of HIV reverse transcriptase RNase H, and allosteric inhibition mechanisms .
Cat. No.: HY-P1341
CAS No.: 343268-91-7
Synonyms: Orexin A (17-33) (human, mouse, rat, bovine)
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Cat. No.: HY-P4118
CAS No.: 952754-66-4
Synonyms: Penetrating analog
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Cat. No.: HY-P11012
Cat. No.: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
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Cat. No.: HY-P10319
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Cat. No.: HY-150536
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EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity .
Cat. No.: HY-P3916
CAS No.: 136831-50-0
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Cat. No.: HY-P5827
CAS No.: 2416761-69-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
