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Results for "

antipruritic

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

6

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12532
    Astemizole
    Maximum Cited Publications
    8 Publications Verification

    R 43512

    		 Histamine Receptor Potassium Channel Inflammation/Immunology Endocrinology
    Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K + channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects .
    Astemizole
  • HY-13508
    JNJ-7777120
    1 Publications Verification

    		 Histamine Receptor Inflammation/Immunology
    JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory .
    JNJ-7777120
  • HY-N0808
    Camphor
    3 Publications Verification

    (±)-Camphor

    		 Environmental Pollutants TRP Channel Influenza Virus Infection Inflammation/Immunology Cancer
    Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
    Camphor
  • HY-12752A
    Alimemazine hemitartrate

    Trimeprazine hemitartrate

    		 Histamine Receptor Influenza Virus Neurological Disease Inflammation/Immunology Cancer
    Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice .
    Alimemazine hemitartrate
  • HY-B0473
    Tetracaine hydrochloride

    Amethocaine hydrochloride

    		 Environmental Pollutants Calcium Channel Neurological Disease
    Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca 2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .
    Tetracaine hydrochloride
  • HY-B0878
    Halobetasol propionate
    1 Publications Verification

    BMY-30056; CGP-14458; Ulobetasol propionate

    		 Glucocorticoid Receptor Inflammation/Immunology
    Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
    Halobetasol propionate
  • HY-101189
    JNJ-39758979

    		Histamine Receptor Neurological Disease Endocrinology
    JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity .
    JNJ-39758979
  • HY-147276
    Izuforant

    JW1601

    		 Histamine Receptor Inflammation/Immunology
    Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies .
    Izuforant
  • HY-B0971
    Pheniramine maleate

    Prophenpyridamine maleate; Tripoton maleate

    		 Histamine Receptor Apoptosis Inflammation/Immunology Endocrinology
    Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .
    Pheniramine maleate
  • HY-155830
    Morcamilast

    ME3183; PDE4-IN-14

    		 Phosphodiesterase (PDE) Interleukin Related Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Morcamilast (ME3183) is a selective and orally active PDE4 inhibitor, with IC50s of 1.28 nM (PDE4A1A), 2.33 nM (PDE4B1), and 1.63 nM (PDE4D2) respectively. Morcamilast shows weak inhibition of PDEs other than PDE4s Morcamilast is an anti-inflammatory agent and inhibits LPS (HY-D1056)-induced release of TNF-α, IL-12/23p40, IL-23, and IL-17A in human PBMCs and T cells. Morcamilast has antipruritic effect and can be used in the study of psoriasis, atopic dermatitis, and other inflammatory diseases .
    Morcamilast
  • HY-N0808R
    Camphor (Standard)

    (±)-Camphor (Standard)

    		 Reference Standards TRP Channel Influenza Virus Infection Inflammation/Immunology Cancer
    Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
    Camphor (Standard)
  • HY-145153
    S-777469

    		Cannabinoid Receptor Neurological Disease
    S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism .
    S-777469
  • HY-101188
    INCB38579

    		Histamine Receptor Infection
    INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities .
    INCB38579
  • HY-107949
    Flumethasone pivalate

    Flumethasone 21-pivalate

    		 Glucocorticoid Receptor Cardiovascular Disease Inflammation/Immunology
    Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis .
    Flumethasone pivalate
  • HY-B0971A
    Pheniramine

    Prophenpyridamine; Tripoton; Pheniramine solution

    		 Histamine Receptor Apoptosis Inflammation/Immunology Cancer
    Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .
    Pheniramine
  • HY-12752
    Alimemazine

    Trimeprazine

    		 Histamine Receptor Neurological Disease Inflammation/Immunology Cancer
    Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .
    Alimemazine
  • HY-12532S
    Astemizole-d3

    		Isotope-Labeled Compounds Histamine Receptor Potassium Channel Inflammation/Immunology Endocrinology
    Astemizole-d3 is the deuterium labeled Astemizole. Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects .
    Astemizole-d3
  • HY-12532R
    Astemizole (Standard)

    R 43512 (Standard)

    		 Reference Standards Histamine Receptor Potassium Channel Inflammation/Immunology Endocrinology
    Astemizole (Standard) is the analytical standard of Astemizole. This product is intended for research and analytical applications. Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K + channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects .
    Astemizole (Standard)
  • HY-120541
    ST-1006

    		Histamine Receptor Inflammation/Immunology
    ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect .
    ST-1006
  • HY-B0878R
    Halobetasol propionate (Standard)
    1 Publications Verification

    BMY-30056 (Standard); CGP-14458 (Standard); Ulobetasol propionate (Standard)

    		 Reference Standards Glucocorticoid Receptor Inflammation/Immunology
    Halobetasol propionate (Standard) (BMY-30056 (Standard)) is the analytical standard of Halobetasol propionate (HY-B0878). This product is intended for research and analytical applications. Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
    Halobetasol propionate (Standard)
  • HY-107949R
    Flumethasone pivalate (Standard)

    Flumethasone 21-pivalate (Standard)

    		 Glucocorticoid Receptor Reference Standards Cardiovascular Disease Inflammation/Immunology
    Flumethasone pivalate (Flumethasone 21-pivalate) (Standard) is the analytical standard of Flumethasone pivalate (HY-107949). This product is intended for research and analytical applications. Flumethasone pivalate is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis .
    Flumethasone pivalate (Standard)
  • HY-101189B
    JNJ-39758979 dihydrochloride

    		Histamine Receptor Inflammation/Immunology
    JNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H4 receptor antagonist, with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 dihydrochloride functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 dihydrochloride shows good anti-inflammatory and antipruritic activity .
    JNJ-39758979 dihydrochloride
  • HY-13508R
    JNJ-7777120 (Standard)

    		Histamine Receptor Inflammation/Immunology
    JNJ-7777120 (Standard) is the analytical standard of JNJ-7777120. This product is intended for research and analytical applications. JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory .
    JNJ-7777120 (Standard)
  • HY-B0971R
    Pheniramine maleate (Standard)

    Prophenpyridamine maleate (Standard); Tripoton maleate (Standard); Pheniramine maleate (Standard)

    		 Reference Standards Histamine Receptor Apoptosis Inflammation/Immunology Endocrinology
    Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .
    Pheniramine maleate (Standard)
  • HY-B0971AR
    Pheniramine (Standard)

    Prophenpyridamine (Standard); Tripoton (Standard); Pheniramine solution (Standard)

    		 Reference Standards Histamine Receptor Apoptosis Inflammation/Immunology Cancer
    Pheniramine (Standard) is the analytical standard of Pheniramine. This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .
    Pheniramine (Standard)
  • HY-12752AR
    Alimemazine hemitartrate (Standard)

    Trimeprazine hemitartrate (Standard)

    		 Reference Standards Histamine Receptor Neurological Disease Inflammation/Immunology Cancer
    Alimemazine hemitartrate (Standard) is the analytical standard of Alimemazine hemitartrate. This product is intended for research and analytical applications. Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.
    Alimemazine hemitartrate (Standard)
  • HY-120541A
    ST-1006 Maleate

    		Histamine Receptor Inflammation/Immunology
    ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect .
    ST-1006 Maleate
  • HY-N9271R
    Grifolin (Standard)

    		Apoptosis Reference Standards Cancer
    Flumethasone pivalate (Standard) is the analytical standard of Flumethasone pivalate. This product is intended for research and analytical applications. Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities .
    Grifolin (Standard)
  • HY-B0473R
    Tetracaine hydrochloride (Standard)

    Amethocaine hydrochloride (Standard)

    		 Reference Standards Calcium Channel Neurological Disease
    Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .
    Tetracaine hydrochloride (Standard)
  • HY-N6777R
    Penicillic acid (Standard)

    		Reference Standards Caspase Bacterial Apoptosis Antibiotic Infection Cancer
    Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .
    Penicillic acid (Standard)
  • HY-B0878S
    Halobetasol propionate-d5

    BMY-30056-d5; CGP-14458-d5; Ulobetasol propionate-d5

    		 Isotope-Labeled Compounds Glucocorticoid Receptor Inflammation/Immunology
    Halobetasol propionate-d5 (BMY-30056-d5) is deuterium labeled Halobetasol propionate (HY-B0878). Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
    Halobetasol propionate-d5
  • HY-12752BS
    Alimemazine-d6 hydrochloride

    Trimeprazine-d6 hydrochloride

    		 Histamine Receptor Isotope-Labeled Compounds Neurological Disease Inflammation/Immunology Cancer
    Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .
    Alimemazine-d6 hydrochloride
  • HY-N7814R
    2-Hydroxypalmitic acid (Standard)

    		Reference Standards Endogenous Metabolite Others
    Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .
    2-Hydroxypalmitic acid (Standard)
  • HY-101189R
    JNJ-39758979 (Standard)

    		Histamine Receptor Reference Standards Neurological Disease Endocrinology
    JNJ-39758979 (Standard) is the analytical standard of JNJ-39758979 (HY-101189). This product is intended for research and analytical applications. JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity .
    JNJ-39758979 (Standard)
  • HY-W585892
    Isopropyl (1S)-(+)-10-camphorsulfate

    		Drug Intermediate Others
    Isopropyl (1S)-(+)-10-camphorsulfate is an impurity of Camphor (HY-N0808). Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative.
    Isopropyl (1S)-(+)-10-camphorsulfate
  • HY-183773
    KOR agonist-9

    		Opioid Receptor Neurological Disease
    KOR agonist-9 is a selective kappa opioid receptor (KOR) agonist with an EC50 of 1.41 nM. KOR agonist-9 exhibits >125-fold selectivity over μ/δ-opioid receptors. KOR agonist-9 antinociceptive and antipruritic effects in mice. KOR agonist-9 can be used for the research of pain, pruritus .
    KOR agonist-9
  • HY-W665882
    Norketotifen

    		TNF Receptor Parasite Drug Metabolite Infection Inflammation/Immunology
    Norketotifen is the active metabolite of Ketotifen (HY-B0157). Norketotifen exhibits skin anti-inflammatory activity, anti-malarial activity, and antipruritic activity against non-histamine-mediated dog itching in mice. Norketotifen effectively inhibits TNF-α release without causing any sedative side effects. Norketotifen can be used for research on non-sedating anti-inflammatory agents .
    Norketotifen
  • HY-N16814
    Balsaminone B

    		Drug Derivative Others
    Balsaminone B is a natural quinone compound.
    Balsaminone B
  • HY-182517
    AG1529

    		TRP Channel Inflammation/Immunology
    AG1529 is a TRPV1 inhibitor and capsaicinoid-based soft agent with a human TRPV1 IC50 of 0.9-0.93 μM. AG1529 reversibly blocks capsaicin-evoked TRPV1 activation, binds to the TRPV1 capsaicin binding site, moderately affects pH-induced TRPV1 gating, and does not alter voltage- or heat-mediated TRPV1 responses. AG1529 suppresses TRPV1-mediated neuronal excitability, reduces capsaicin- and pH-evoked neuronal firing, abolishes histaminergic and inflammation-mediated TRPV1 sensitization. AG1529 exhibits anti-nociceptive and antipruritic effects, attenuates in vivo hyperalgesia and pruritus, dose-dependently reduces acute histaminergic itch in rodents, and mildly blocks hTRPA1 and hTRPM8 channel activity. AG1529 undergoes hydrolysis and dermal deactivation, minimizes TRPV1-associated side reactions, does not evoke capsaicin-like burning sensation, and does not disrupt physiological thermal regulation. AG1529 can be used for the research of inflammatory cutaneous nociception and acute histaminergic pruritus .
    AG1529

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