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Results for "

cage

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Biochemical Assay Reagents (1) Dopamine Receptor (1) Endogenous Metabolite (1) GABA Receptor (2) iGluR (1) mGluR (2) nAChR (1) Potassium Channel (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (1) Metabolic Disease (2) Neurological Disease (12)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153890

*NVOC cage-TMP-Halo*	Others	Others
NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .

HY-RS01825

CAGE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAGE1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAGE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAGE1 Human Pre-designed siRNA Set A CAGE1 Human Pre-designed siRNA Set A

HY-136283

DMNPE-4 AM-caged-calcium	Others	Neurological Disease
DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca ²⁺ selective cage, with a K_d for Ca ²⁺ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca ²⁺ (K_d=~2 nM) after photolysis .

HY-103235

NPEC-caged-(S)-AMPA	iGluR	Neurological Disease
NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively activates AMPA receptor .

HY-126789A

DM-Nitrophen tertasodium	Others	Others
DM-Nitrophen tertasodium is a Ca ²⁺ cage. DM-Nitrophen releases Ca ²⁺ when cleaved upon illumination with near-ultraviolet light . DM-Nitrophen tertasodium can be used for study of Ca ²⁺ signaling .

HY-126789

DM-Nitrophen

Others Others

DM-Nitrophen is a Ca ²⁺ cage. DM-Nitrophen releases Ca ²⁺ when cleaved upon illumination with near-ultraviolet light .
HY-115231

ci-IP3/PM

Others Others

ci-IP3/PM is a caged and cell permeable derivative of IP3. ci-IP3/PM can induce Ca ²⁺ release from internal stores .

DM-Nitrophen	Others	Others
DM-Nitrophen is a Ca ²⁺ cage. DM-Nitrophen releases Ca ²⁺ when cleaved upon illumination with near-ultraviolet light .

ci-IP3/PM	Others	Others
ci-IP3/PM is a caged and cell permeable derivative of IP3. ci-IP3/PM can induce Ca ²⁺ release from internal stores .

HY-103527

RuBi-GABA	GABA Receptor	Neurological Disease
RuBi-GABA is a new ruthenium-based caged GABA compound. RuBi-GABA photocleaves and releases GABA after being excited with visible wavelengths. RuBi-GABA produces gaba receptor-mediated currents .

HY-N2427

Adamantane	Others	Others
Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

HY-103427

NPEC-caged-dopamine	Dopamine Receptor	Neurological Disease
NPEC-caged-dopamine is a caged version of dopamine. NPEC-caged-Dopamine was used by applying focal photolysis with UV light (360 nm) to releases dopamine, which leads to D1 receptor activation .

HY-136276

DMNB-caged-Serine	Others	Others
DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation .

HY-131039

MDNI-caged-L-glutamate MDNI-glu	Amino Acid Derivatives	Others
MDNI-caged-L-glutamate (MDNI-glu) is a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate. MDNI-caged-L-glutamate makes more efficient use of incident light .

HY-N8727

Isomorellic acid

Others Cancer

Isomorellic acid is a cytotoxic caged xanthone and can be used for cancer research .
HY-110304

NPEC-caged-LY379268

mGluR Neurological Disease

NPEC-caged-LY379268 is a type II mGluR agonist .
HY-107520

MNI-caged-L-glutamate

Others Neurological Disease

MNI-caged-L-glutamat is a reagent that can release neuroactive amino acids quickly and efficiently .
HY-107520A

MNI-caged-L-glutamate TFA

Others

MNI-caged-L-glutamate TFA is a reagent capable of rapidly and efficiently releasing neuroactive amino acids .
HY-153056

BNN3

Others Others

BNN3 is a caged nitric oxide (NO) donor. BNN3 is membrane-permeant and incorporated in the lipid membrane .
HY-103555

NPEC-caged-(1S,3R)-ACPD

Biochemical Assay Reagents Others

NPEC-caged-(1S,3R)-ACPD is a specific photosensitive ligand for glutamate receptor subtypes.

Isomorellic acid	Others	Cancer
Isomorellic acid is a cytotoxic caged xanthone and can be used for cancer research .

NPEC-caged-LY379268	mGluR	Neurological Disease
NPEC-caged-LY379268 is a type II mGluR agonist .

MNI-caged-L-glutamate	Others	Neurological Disease
MNI-caged-L-glutamat is a reagent that can release neuroactive amino acids quickly and efficiently .

MNI-caged-L-glutamate TFA	Others
MNI-caged-L-glutamate TFA is a reagent capable of rapidly and efficiently releasing neuroactive amino acids .

BNN3	Others	Others
BNN3 is a caged nitric oxide (NO) donor. BNN3 is membrane-permeant and incorporated in the lipid membrane .

NPEC-caged-(1S,3R)-ACPD	Biochemical Assay Reagents	Others
NPEC-caged-(1S,3R)-ACPD is a specific photosensitive ligand for glutamate receptor subtypes.

HY-103526

DPNI-GABA	GABA Receptor	Neurological Disease
DPNI-GABA is a nitroindoline cage compound that inhibits GABA(A) receptors and reduces GABA-evoked peak responses with an IC₅₀ value of 0.5 mM .

HY-131885

RuBi-Glutamate hexafluorophosphate sodium	Others	Neurological Disease
RuBi-Glutamate hexafluorophosphate sodium is a novel cage glutamate compound based on ruthenium photochemistry. RuBi-Glutamate hexafluorophosphate sodium can be excited at visible wavelengths and release glutamate after single or two-photon excitation. It has high quantum efficiency and can be used at low concentrations, partially avoiding the blocking of GABA energy transmission by other cage compounds. Two-photon release of RuBi-Glutamate hexafluorophosphate sodium has high spatial resolution and produces a physiodynamic excitatory response in a single dendritic spine .

HY-107689

RuBiNic	Others	Neurological Disease
RuBiNic is a cage compound based on the photochemistry of Ru-bpy complexes and releases nicotine by irradiation with visible light up to 532 nm. RuBiNic is able to induce action potentials in Retzius neurons with 473 nm laser .

HY-N10256

Varioxepine A	Endogenous Metabolite	Infection
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .

HY-N7502

2-(Hydroxymethyl)anthraquinone	Others	Others
2-(Hydroxymethyl)anthraquinone is used as a photoremovable protecting group (PRPG) to chemically cage sex pheromone (e.g. (Z)-11-hexadecen-1-ol (sex pheromone of Chilo infuscatellussnellen)) .

HY-131019

JF-NP-26	mGluR	Neurological Disease
JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .

HY-161005

TETS-Methyl benzoate	Others	Metabolic Disease
TETS-Methyl benzoate(compound 2j) is a haptendirectly conjugated to the carrier protein via carboxylic acid function using the standard activated ester method .

HY-156906

UNC3474	Others	Cancer
UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1 ^TT, with a dissociation constant (K_d) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells .

HY-131001

DPNB-ABT594	nAChR	Neurological Disease
DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR‐mediated Ca ²⁺ signalling in the MHb .

HY-108578

RuBi-4AP	Potassium Channel	Neurological Disease
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged K_v channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .

Asfotase alfa ENB-0040	Inhibitory Antibodies	Metabolic Disease
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 ^−/− knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .

Adamantane	Structural Classification Natural Products Classification of Application Fields Other Diseases Plants Minerals Disease Research Fields	Others
Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

2-(Hydroxymethyl)anthraquinone	Quinones Classification of Application Fields Anthraquinones Source classification Other Diseases Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	Others
2-(Hydroxymethyl)anthraquinone is used as a photoremovable protecting group (PRPG) to chemically cage sex pheromone (e.g. (Z)-11-hexadecen-1-ol (sex pheromone of Chilo infuscatellussnellen)) .

Isomorellic acid	Structural Classification Ketones, Aldehydes, Acids Guttiferae Plants Garcinia hanburyi Hook. f.	Others
Isomorellic acid is a cytotoxic caged xanthone and can be used for cancer research .

Varioxepine A	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Endogenous Metabolite
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .

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