UNC3474

Cat. No.: HY-156906 Purity: 98.15%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1^TT, with a dissociation constant (K_d) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells.

For research use only. We do not sell to patients.

UNC3474 Chemical Structure

CAS No. : 1648707-79-2

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Unlike WT 53BP1^TT, 53BP1^TT-PN dose not interact with UNC3474^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.42

Formula

C₁₇H₂₈N₂O

CAS No.

1648707-79-2

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CC(C(C)C)=C1)NCCCNC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (361.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6177 mL	18.0884 mL	36.1768 mL
5 mM	0.7235 mL	3.6177 mL	7.2354 mL
10 mM	0.3618 mL	1.8088 mL	3.6177 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.15%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (242 KB) HNMR (250 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Cui G, et al. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. bioRxiv [Preprint]. 2023 Jul 18:2023.04.20.534960. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6177 mL	18.0884 mL	36.1768 mL	90.4421 mL
	5 mM	0.7235 mL	3.6177 mL	7.2354 mL	18.0884 mL
	10 mM	0.3618 mL	1.8088 mL	3.6177 mL	9.0442 mL
	15 mM	0.2412 mL	1.2059 mL	2.4118 mL	6.0295 mL
	20 mM	0.1809 mL	0.9044 mL	1.8088 mL	4.5221 mL
	25 mM	0.1447 mL	0.7235 mL	1.4471 mL	3.6177 mL
	30 mM	0.1206 mL	0.6029 mL	1.2059 mL	3.0147 mL
	40 mM	0.0904 mL	0.4522 mL	0.9044 mL	2.2611 mL
	50 mM	0.0724 mL	0.3618 mL	0.7235 mL	1.8088 mL
	60 mM	0.0603 mL	0.3015 mL	0.6029 mL	1.5074 mL
	80 mM	0.0452 mL	0.2261 mL	0.4522 mL	1.1305 mL
	100 mM	0.0362 mL	0.1809 mL	0.3618 mL	0.9044 mL

UNC3474 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC34741648707-79-2UNC 3474UNC-3474OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks