1648707-79-2
1648707-79-2
Chemical Structure
UNC3474
- CAS No.: 1648707-79-2
- Formula:C17H28N2O
- Molecular Weight:276.42
InChIKey: CNTJLQUUYDXEFL-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C(C)C)=C1)NCCCNC(C)(C)C
Biological Activity: UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UNC3474 | 98.56% | UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-115531UNC-2170 -
Similarity Score 0.67
HY-16739Emeramide -
Similarity Score 0.66
HY-174814Jun15716 -
Similarity Score 0.66
HY-118897UNC-2170 maleate -
Similarity Score 0.62
HY-A0084AProcainamide -
Similarity Score 0.62
HY-13733AProcarbazine -
Similarity Score 0.62
HY-A0084Procainamide hydrochloride -
Similarity Score 0.62
HY-W7033762-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride -
Similarity Score 0.62
HY-1587563-EEC hydrochloride -
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