RuBi-Glutamate hexafluorophosphate sodium

Name: RuBi-Glutamate hexafluorophosphate sodium
Brand: MedChemExpress
SKU: HY-131885
Rating: 4.5 (1 reviews)

Cat. No.: HY-131885 Purity: 82.94%: Data Sheet
COA

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RuBi-Glutamate hexafluorophosphate sodium is a neuronal activator. RuBi-Glutamate hexafluorophosphate sodium photocleaves to release glutamate upon one- or two-photon excitation, activating glutamate receptors in cortical pyramidal neurons. RuBi-Glutamate hexafluorophosphate sodium reduces peak amplitude of evoked GABAergic inhibitory postsynaptic currents in its caged form. RuBi-Glutamate hexafluorophosphate sodium can be used for the research of Huntington's disease.

For research use only. We do not sell to patients.

RuBi-Glutamate hexafluorophosphate sodium Chemical Structure

CAS No. : 2417096-44-5

Size	Stock	Quantity
5 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

RuBi-Glutamate (3 mM) hexafluorophosphate sodium induces a 41% smaller intracellular sodium transient (a marker of glutamate transport activity) in SR101⁺ striatal astrocytes from Q175 homozygous Huntington's disease (HD) mice compared to WT mice after photolytic uncaging^[2].
RuBi-Glutamate (0.1-3 mM) hexafluorophosphate sodium induces GTCs in SR101⁺ striatal astrocytes that are significantly smaller in Q175 homozygous HD mice than WT mice after photolytic uncaging^[2].
RuBi-Glutamate (1 mM) hexafluorophosphate sodium induces Glutamate-induced spine current (GISCs) in WT striatal projection neurons^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

970.54

Formula

C₂₈H₃₂F₁₂N₅Na₂O₄P₃Ru

CAS No.

2417096-44-5

Appearance

Solid

Color

Orange to red

SMILES

[F-][P+5]([F-])([F-])([F-])([F-])[F-].O=C(O[Na])[C@H](CCC(O[Na])=O)[NH2][Ru+2]12([N]3=CC=CC=C3C4=CC=CC=[N]14)([N]5=CC=CC=C5C6=CC=CC=[N]26)[P](C)(C)C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 19.41 mg/mL (20.00 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0304 mL	5.1518 mL	10.3035 mL
5 mM	0.2061 mL	1.0304 mL	2.0607 mL
10 mM	0.1030 mL	0.5152 mL	1.0304 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 82.94%

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Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Fino E, et al. RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines. Front Neural Circuits. 2009;3:2. Published 2009 May 27. [Content Brief]

[2]. Dvorzhak A, et al. Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice. J Neurosci. 2016;36(18):4959-4975.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0304 mL	5.1518 mL	10.3035 mL	25.7589 mL
	5 mM	0.2061 mL	1.0304 mL	2.0607 mL	5.1518 mL
	10 mM	0.1030 mL	0.5152 mL	1.0304 mL	2.5759 mL
	15 mM	0.0687 mL	0.3435 mL	0.6869 mL	1.7173 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.