RuBi-Glutamate hexafluorophosphate sodium
RuBi-Glutamate hexafluorophosphate sodium is a neuronal activator. RuBi-Glutamate hexafluorophosphate sodium photocleaves to release glutamate upon one- or two-photon excitation, activating glutamate receptors in cortical pyramidal neurons. RuBi-Glutamate hexafluorophosphate sodium reduces peak amplitude of evoked GABAergic inhibitory postsynaptic currents in its caged form. RuBi-Glutamate hexafluorophosphate sodium can be used for the research of Huntington's disease.
For research use only. We do not sell to patients.
- Purity: 82.94%
- CAS No.: 2417096-44-5
- Formula: C28H32F12N5Na2O4P3Ru
- Molecular Weight:970.54
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RuBi-Glutamate (3 mM) hexafluorophosphate sodium induces a 41% smaller intracellular sodium transient (a marker of glutamate transport activity) in SR101+ striatal astrocytes from Q175 homozygous Huntington's disease (HD) mice compared to WT mice after photolytic uncaging[2].
RuBi-Glutamate (0.1-3 mM) hexafluorophosphate sodium induces GTCs in SR101+ striatal astrocytes that are significantly smaller in Q175 homozygous HD mice than WT mice after photolytic uncaging[2].
RuBi-Glutamate (1 mM) hexafluorophosphate sodium induces Glutamate-induced spine current (GISCs) in WT striatal projection neurons[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417096-44-5
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Appearance Solid
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Molecular Weight 970.54
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Formula C28H32F12N5Na2O4P3Ru
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Color Orange to red
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SMILES
[F-][P+5]([F-])([F-])([F-])([F-])[F-].O=C(O[Na])[C@H](CCC(O[Na])=O)[NH2][Ru+2]12([N]3=CC=CC=C3C4=CC=CC=[N]14)([N]5=CC=CC=C5C6=CC=CC=[N]26)[P](C)(C)C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : 19.41 mg/mL (20.00 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Fino E, et al. RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines. Front Neural Circuits. 2009;3:2. Published 2009 May 27. [Content Brief]
[2]. Dvorzhak A, et al. Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice. J Neurosci. 2016;36(18):4959-4975. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0304 mL | 5.1518 mL | 10.3035 mL | 25.7589 mL |
| 5 mM | 0.2061 mL | 1.0304 mL | 2.0607 mL | 5.1518 mL | |
| 10 mM | 0.1030 mL | 0.5152 mL | 1.0304 mL | 2.5759 mL | |
| 15 mM | 0.0687 mL | 0.3435 mL | 0.6869 mL | 1.7173 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
RuBi-Glutamate hexafluorophosphate sodium Related Classifications
HY-131885 Related Classifications
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