DPNB-ABT594
DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR-mediated Ca2+ signalling in the MHb.
For research use only. We do not sell to patients.
- Formula: C31H46ClN3O11
- Molecular Weight:672.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Target: α4β2 nAChR; α7 nAChR[1]
DPNB-ABT594 (20 μM) exhibits large inward currents and Ca2+ transients in response to laser uncaging at 410 nm at the soma, which increases linearly with energy dosage as expected for one-photon excitation (1 mW, 0.5-3 ms)[1]. DPNB-ABT594 is suitable for one- or two-photon photolysis, it evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices, following exposure to 410 nm light[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 672.16
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Formula C31H46ClN3O11
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SMILES
ClC1=NC=C(OC[C@@H]2N(C(C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O)C)CC2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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