1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. DPNB-ABT594

DPNB-ABT594 

Cat. No.: HY-131001
Handling Instructions

DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR‐mediated Ca2+ signalling in the MHb.

For research use only. We do not sell to patients.

DPNB-ABT594 Chemical Structure

DPNB-ABT594 Chemical Structure

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Description

DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR‐mediated Ca2+ signalling in the MHb[1].

IC50 & Target

Target: α4β2 nAChR; α7 nAChR[1]

In Vitro

DPNB‐ABT594 (20 μM) exhibits large inward currents and Ca2+ transients in response to laser uncaging at 410 nm at the soma, which increases linearly with energy dosage as expected for one‐photon excitation (1 mW, 0.5-3 ms)[1].
DPNB‐ABT594 is suitable for one- or two-photon photolysis, it evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices, following exposure to 410 nm light[1].

Molecular Weight

672.16

Formula

C₃₁H₄₆ClN₃O₁₁

SMILES

ClC1=NC=C(OC[[email protected]@H]2N(C(C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O)C)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DPNB-ABT594nAChRNicotinic acetylcholine receptorsneuronmedial habenulanitrobenzyl-cagedCa2+?transientsInhibitorinhibitorinhibit

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DPNB-ABT594
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HY-131001
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