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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
corneal endothelial cells
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "corneal endothelial cells" in MCE Product Catalog:
49
49 Publications Verification
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .
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2 Cited Publications
Cat. No.: HY-P4846
CAS No.: 292171-04-1
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1 Cited Publications
Synonyms: HMS; 6α-Methyl-11β-hydroxyprogesterone
Research Areas:
Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and CCL2. Medrysone also enhances the pro-migratory activity of M2-like macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury .
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1 Cited Publications
(+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity .
Cat. No.: HY-E70005K
CAS No.: 9001-12-1
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Collagenase (Type A, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .
Cat. No.: HY-E70005M
CAS No.: 9001-12-1
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Collagenase (Type C, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .
Cat. No.: HY-Y0850U3
CAS No.: 9002-89-5
Synonyms: Polyvinyl alcohol (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization); Poly(Ethenol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization)
Cat. No.: HY-176886
CAS No.: 2248728-49-4
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LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction .
Synonyms: SIM010603
Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .
Cat. No.: HY-E70005O
CAS No.: 9001-12-1
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Collagenase (Type A, filtered, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .
Cat. No.: HY-13813R
CAS No.: 674289-55-5
Blebbistatin (Standard) is the analytical standard of Blebbistatin. This product is intended for research and analytical applications. Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .
Cat. No.: HY-17495
CAS No.: 51781-06-7
Synonyms: OPC-1085
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Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research .
Synonyms: HMS (Standard); 6α-Methyl-11β-hydroxyprogesterone (Standard)
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Medrysone (Standard) is the analytical standard of Medrysone. This product is intended for research and analytical applications. Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and CCL2. Medrysone also enhances the pro-migratory activity of M2-like macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury .
Cat. No.: HY-123864
CAS No.: 188804-07-1
Synonyms: S 448
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SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM). SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors .
Cat. No.: HY-DY2045
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Alizarin Red S Staining Solution (2%, pH 4.2) is a 2% concentration, pH 4.2 anthraquinone dye (sodium alizarin sulfonate) that can be used for intercellular staining of corneal endothelial cell boundaries. Alizarin Red S Staining Solution (2%, pH 4.2) is an anthraquinone dye (sodium alizarin sulfonate) with an optimized pH of 4.2, which undergoes a dye-lake reaction with calcium and serves as an intercellular stain for corneal endothelial cell boundaries. Alizarin Red S Staining Solution (2%, pH 4.2) can be used for screening tests of calcium compounds in synovial fluid, detection of osteoblast differentiation, and staining detection of bone in mice. Excitation/emission wavelength: 500/570 nm .
Cat. No.: HY-DY2044
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Alizarin Red S Staining Solution (1%, pH 4.2) is an anthraquinone dye (sodium alizarinsulfonate) with an optimized pH of 4.2. It undergoes a dye-lake reaction with calcium and serves as an intercellular stain for the boundaries of corneal endothelial cells. Alizarin Red S Staining Solution (1%, pH 4.2) enables screening tests for calcium compounds in synovial fluid, detection of osteoblast differentiation, and staining detection of bone in mice. Excitation/emission wavelength: 500/570 nm .
Cat. No.: HY-P11775A
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Cat. No.: HY-P11775
CAS No.: 1228536-06-8
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Cat. No.: HY-107657R
CAS No.: 1177356-70-5
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(+)-Blebbistatin (Standard) is the analytical standard of (+)-Blebbistatin (HY-107657). This product is intended for research and analytical applications. (+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity .
Cat. No.: HY-184656
CAS No.: 3099422-14-4
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VEGFR/PDGFR/CA II-IN-1 is a VEGFR/PDGFR/CA II inhibitor. VEGFR/PDGFR/CA II-IN-1 potently inhibits VEGFR2 (IC50 = 62.66 nM), PDGFRα (IC50 = 18.65 nM), PDGFRβ (IC50 = 5.23 nM), and hCA II (Ki = 19.4 nM), with weaker activity against hCA I (Ki = 154.2 nM) and hCA IX (Ki = 121.0 nM). VEGFR/PDGFR/CA II-IN-1 exhibits potent antiproliferative activity in VEGFR2-BAF3 cells and robust inhibition of angiogenesis in human umbilical vein endothelial cells (HUVECs). VEGFR/PDGFR/CA II-IN-1 inhibits the formation of corneal neovascularization in rabbits through multiple signaling pathways, and significantly reduced intraocular pressure (IOP) in both acute and chronic glaucoma models. VEGFR/PDGFR/CA II-IN-1 can be used to study neovascular glaucoma (NVG) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
