SC-68448
SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM). SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors.
For research use only. We do not sell to patients.
- CAS No.: 188804-07-1
- Formula: C19H19Cl2N5O4
- Molecular Weight:452.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 188804-07-1
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Molecular Weight 452.29
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Formula C19H19Cl2N5O4
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SMILES
O=C(O)CC(NC(CNC(C1=CC=CC(NC(N)=N)=C1)=O)=O)C2=CC(Cl)=CC(Cl)=C2
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Synonyms
S 448
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Carron CP,et al. A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res. 1998 May 1;58(9):1930-5. [Content Brief]
[2]. Roper JA, et al. Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent. J Pharmacol Exp Ther. 2021 Feb;376(2):273-280. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SC-68448 Related Classifications
HY-123864 Related Classifications
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