2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Peptide HRH acetate

Peptide HRH acetate is a polypeptide that specifically binds to VEGF receptors. Peptide HRH acetate inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH acetate inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH acetate can be used in anti-angiogenesis related studies.

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Peptide HRH acetate

Peptide HRH acetate Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Peptide HRH acetate:

Peptide HRH acetate Related Antibodies

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Description

Peptide HRH acetate is a polypeptide that specifically binds to VEGF receptors. Peptide HRH acetate inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH acetate inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH acetate can be used in anti-angiogenesis related studies[1].

In Vitro

Peptide HRH (0.95-3.85 μg/μL; 96 h) acetate dose-dependently inhibits the proliferation of VEGF-stimulated human umbilical vein endothelial cells (HUVECs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peptide HRH acetate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human umbilical vein endothelial cells (HUVECs) stimulated with VEGF
Concentration: 0.95; 1.9; 3.85 μg/μL
Incubation Time: 96 h
Result: Suppressed the proliferation of VEGF-stimulated HUVECs in a dose-dependent manner.
In Vivo

Peptide HRH (10-50 μg/μL; local application to CAM; 48 h) acetate dose-dependently suppresses angiogenesis in the chick CAM model[1].
Peptide HRH (10 μg/μL; topical eye drops; four times per day; 14 days) acetate significantly inhibits corneal neovascularization in the alkali-burned rat corneal model[1].
Peptide HRH (10 μg/μL; topical eye drops; four times per day; 14 days) acetate significantly inhibits corneal neovascularization in the suture-induced rat corneal model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, alkali-burned corneal model)[1]
Dosage: 10 μg/μL
Administration: topical eye drops; four times per day; 14 days
Result: Significantly reduced corneal neovascularization area from days 3 to 14 post-burn.
Kept most of the corneal stroma free of blood vessels.
Animal Model: Sprague-Dawley (male, suture-induced corneal model)[1]
Dosage: 10 μg/μL
Administration: topical eye drops; four times per day; 14 days
Result: Significantly reduced maximum vessel length and total corneal neovascularization area from days 3 to 14 post-suture.
Molecular Weight

1521.69 (free base)

Formula

C64H104N28O16·xC2H4O2
Appearance

Solid

Color

White to off-white

Sequence

His-Arg-His-Thr-Lys-Gln-Arg-His-Thr-Ala-Leu-His
Sequence Shortening

HRHTKQRHTALH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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Peptide HRH acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peptide HRHVEGFRVascular endothelial growth factor receptorendothelial cell proliferationVEGF-Cangiogenesishuman umbilical vein endothelial cellschick CAM modelVEGF-BVEGF-AVEGFR-2corneal neovascularizationVEGFR-1Inhibitorinhibitorinhibit

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