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Art. -Nr.: HY-P11775A

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Peptide HRH acetate

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Peptide HRH acetate is a polypeptide that specifically binds to VEGF receptors. Peptide HRH acetate inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH acetate inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH acetate can be used in anti-angiogenesis related studies.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 97.16%
Formel: C₆₄H₁₀₄N₂₈O₁₆·xC₂H₄O₂
Molecular Weight:1521.69 (free base)

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Peptide HRH acetate Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle VEGFR Isoform-spezifische Produkte anzeigen :

In Vitro

Peptide HRH (0.95-3.85 μg/μL; 96 h) acetate dose-dependently inhibits the proliferation of VEGF-stimulated human umbilical vein endothelial cells (HUVECs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human umbilical vein endothelial cells (HUVECs) stimulated with VEGF
Concentration:

0.95; 1.9; 3.85 μg/μL
Incubation Time:

96 h
Result:

Suppressed the proliferation of VEGF-stimulated HUVECs in a dose-dependent manner.

In Vivo

Peptide HRH (10-50 μg/μL; local application to CAM; 48 h) acetate dose-dependently suppresses angiogenesis in the chick CAM model^[1].
Peptide HRH (10 μg/μL; topical eye drops; four times per day; 14 days) acetate significantly inhibits corneal neovascularization in the alkali-burned rat corneal model^[1].
Peptide HRH (10 μg/μL; topical eye drops; four times per day; 14 days) acetate significantly inhibits corneal neovascularization in the suture-induced rat corneal model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, alkali-burned corneal model)^[1]
Dosage:

10 μg/μL
Administration:

topical eye drops; four times per day; 14 days
Result:

Significantly reduced corneal neovascularization area from days 3 to 14 post-burn.
Kept most of the corneal stroma free of blood vessels.

Animal Model:

Sprague-Dawley (male, suture-induced corneal model)^[1]
Dosage:

10 μg/μL
Administration:

topical eye drops; four times per day; 14 days
Result:

Significantly reduced maximum vessel length and total corneal neovascularization area from days 3 to 14 post-suture.

Chemical Information

Appearance Solid
Molecular Weight 1521.69 (free base)
Formel C₆₄H₁₀₄N₂₈O₁₆·xC₂H₄O₂
Color White to off-white
Sequence

His-Arg-His-Thr-Lys-Gln-Arg-His-Thr-Ala-Leu-His
Sequence Shortening

HRHTKQRHTALH
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang Y, et al. A novel peptide specifically binding to VEGF receptor suppresses angiogenesis in vitro and in vivo. Signal Transduct Target Ther. 2017 May 12;2:17010. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Peptide HRH acetate

Peptide Library

Alle VEGFR Isoform-spezifische Produkte anzeigen